Study On The Relationship Between Blood Stasis Syndrome And Circulating Endothelial Progenitor Cells In Elderly Patients With Cerebral Atherosclerosis

Objective:To investigate the correlation between the number of circulating endothelial progenitor cells and the degree of cerebral arteriosclerosis and blood stasis syndrome in elderly patients with cerebral atherosclerosis,and enrich the prevention and treatment of cerebral arteriosclerosis by combining traditional Chinese and western medicine.Methods:1.122 elderly patients with brain atherosclerosis were prospectively enrolled and collected the demographic data,atherosclerosis-related risk factors,blood indicators,TCM dialectical information from February 2016 to February 2017 in Neurology and Geriatrics Department of Fujian Provincial Hospital,2.The number of peripheral blood endothelial progenitor cells was detected by flow cytometry.All patients with brain atherosclerosis were divided into two groups according to the cerebral atherosclerosis screening and diagnostic criteria(2014 version),and set the cerebral atherosclerosis grade 1 to be the mild group,grade 2-3 to be the moderate to severe group.Those factors including the number of circulating endothelial progenitor cells,the risk factors of atherosclerosis and the classification of blood stasis syndrome were compared between the two groups.Also,the number of the endothelial progenitor cells,sex,age,risk factors of atherosclerosis were compared between blood stasis syndrome patients and non-blood stasis syndrome patients.Results:1.There were 122 eligible patients aged 80-96 years were included with an average age of(84.20 ± 3.90)years old,including 84 males and 38 females,93 cases of hypertension,43 cases of diabetes,49 cases of coronary heart disease,28 cases of smoking and 16 cases of drinking.There were 102 cases of blood stasis syndrome,and 20 cases were not.2.There were significant difference in age,coronary heart disease,endothelial progenitor count and atherosclerosis between blood stasis group and non-blood stasis group(P<0.05);between blood stasis syndrome score and grade of cerebral arteriosclerosis grade(P = 0.001),and the correlation coefficient was 0.307.The correlation between the score of blood stasis syndrome and the number of endothelial progenitor cells was statistically significant(P ?0.003),which was negatively correlated(the correlation coefficient is-0.265).3.Their were 92 cases who were diagnosed with mild cerebral atherosclerosis,and 30 cases who were diagnosed with moderate to severe cerebral atherosclerosis.Analysing elderly patients with cerebral atherosclerosis through the multiple factors binomial logistic regression analysis.The degree of cerebral arteriosclerosis was the dependent variable,the cerebral atherosclerosis grade 1 was set to be the mild group,and the grade 2-3 was set to moderate to severe group,setting the factors of Diabetes mellitus,coronary heart disease,endothelial progenitor cells,triglyceride,total cholesterol,high density lipoprotein,low density lipoprotein,serum uric acid,creatinine and endothelial progenitor cells as independent variable,(The number of endothelial progenitor cells less than 0.085%was set to be less,and the number of endothelial progenitor cells more than 0.085%was set to be more).The relative risk(OR)of endothelial progenitor cells was 0.13(95%confidence interval(CI):0.05-0.342),P<0.001),which was statistically significant after adjustment for the mixed factors of various risk factors.Conclusions:1.In elderly patients with cerebral atherosclerosis,the more severe the degree of cerebral arteriosclerosis is,the lower the circulating endothelial progenitor cells will be and the more severe the symptoms of blood stasis is,the higher the score of blood stasis syndrome will be,and the cerebral atherosclerosis is also more serious;When the number of endothelial progenitor cells involved in vascular repairing decrease,the risk of stroke may increase.2.The blood stasis syndrome accounts for a large proportion among elderly patients with cerebral atherosclerosis,and it is positively related to the severity of arteriosclerosis.It may be appropriate to use blood circulation drugs to attenuate arteriosclerosis in the patient who is dignosed with blood stasis syndrome.