| Objective:Mucinous endometrial cancer(MEC)is a rare histologic subtype of endometrial cancers.Retrospectively analysis the data of the patients in Mucinous endometrial cancer(MEC)who accepted treatment from Qilu hospital of Shandong University for the past 10 years to explore the clinical and pathological characteristics.The purpose is to explore its new onset tendency and itsclinicopathologic features and some prognostic factors,and then to compare the datas of patients with MEC with patients with endometrioid endometrial cancer(EEC),to determine whether there are significant clinicopathologic differences between these tumors,and then to improvethe understanding of the clinicopathologic features of mucinous endometrial cancer.Methods:The retrospective study is based on clinicical and pathologic data of 23 patients with mucinous endometrial cancer(MEC)and 20 patients with the mixed type of MEC and EEC who accepted treatment in QiLu Hospital of Shandong University from 2006 to 2016.And then to compare with 65 patients with endometrioid endometrial cancer(EEC)from the latter half of the 2015 year.We use excel software to analyze these collected data by descriptive statistics.Results:1.Clinicopathologic features of 23 cases with Mucinous Endometrial Cancer(1).The onset rate of MEC is low,account for 1.44%(1600 cases)of Endometrial Cancer on the same period.(2).The age range of patients is 30 to 73 years old,the average age of onset is 53.78 ± 12.49 years;(3).The main symptoms of the patients were irregular vaginal bleeding,of which 18 cases(78.26%)were discharged,2 cases(8.70%)had abdominal pain and 3 cases(13.04%)with no obvious clinical manifestations.(4).There were 8 patients(34.78%)with hypertension,1 patient(4.35%)with diabetes,2 cases(8.70%)with infertility.(5).All patients underwent surgical treatment.Most of them about 13cases(56.52%)were treated with hysterectomy,bilateral appendectomy,pelvic lymph node dissection/abdominal aortic lymph node sampling.(6).There were 22 cases(95.65%)with definite histological grade,among which there were 11 cases(47.83%)in G1 grade and 12 cases(52.17%)in G2/G3.(7).15 cases(15.32%)in stage ?,4 cases(17.39%)in stage ?,3 cases(13.04%)in stage ?,1 case(4.35%)in stage ? and 3 cases(13.04%)in pelvic metastasis,1 case(4.35%)of lymph node metastasis.(8).There were 14 patients(60.87%)with immunohistochemistry,13 cases(92.86%)with ER and PR(+),and 1 case(7.14%)were negative.And there were 2 cases(8.70%)with CEA(+);(9).9 cases(39.13%)undergo postoperative chemotherapy,2 cases(8.70%)had postoperative radiotherapy;(10).The follow-up time were 5 to 83 months.The mean follow-up time was 27.6 months.The median follow-up time was 20 months.The follow-up rate was 82.61%.There was no recurrence or death.2.Endometrial mucinous adenocarcinoma(1st group)23 cases,EEC mixed with MEC(2nd groups)20 cases,endometrioid adenocarcinoma(3rd groups)65 cases:(1).There was no statistically significant difference in onset ages and in the number and age of postmenopausal women within the three group(P>0.05).(2).The main clinical manifestations of three groups were irregular vaginal bleeding,drainage,and there was no statistically significant difference within the three group(P>0.05).And there was no statistically significant difference within the three group(P>0.05)in the women combined with hypertension,diabetes,infertility and other complications;(3).The main operation of the three groups were all hysterectomy,bilateral appendectomy,pelvic lymph nodes/abdominal aortic lymph nodes dissection,and there was no statistically significant difference within the three group(P>0.05);there were no significant differences in histological grade within the three group(P>0.05);(4).There were no significant differences in stage and the pelvic or lymph node metastasis within the three group(P>0.05).(5).There was no statistically significant difference within the three group(P>0.05)in the portion of positive ER.PR:Conclusion:1.Mucinous endometrial cancer is a rare tumor in women,the incidence is low,accounting for about 1.44%of endometrial cancer(1 600 cases)on the same period.2.The main clinical manifestations of MEC is irregular vaginal bleeding,the main complications are hypertension,diabetes and infertility;3.Surgical treatment is the main treatment,most of the surgical methods using hysterectomy,bilateral attachment resection,pelvic lymph node dissection/abdominal aortic lymph node sampling,surgical staging mainly for the first stage,mainly for the well-different histology,ER,PR positive rate is higher,but CEA positive rate is low;4.Pelvic and lymph node metastasis rate is high,but tend to a better prognosis.5.There was no significant difference in age,menopause,comorbidities,major clinical manifestations,surgical methods,stage,pelvic and lymph node metastasis,histological grade,and ER,PR(+)composition compared with EEC. |
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