Study On The Blood Rheology Situation And Its Influencing Factors Among The Groups In Varied Water Iodine Regions

Objective:This study is to investigate the blood rhelogy situation and its influencing factors among the groups in varied water iodine regions in Shandong province,through which we could explore the effect water iodine and other influencing factors do on blood rhelogy and cardiovascular system,and provide practical strategy for cardiovascular diseases preventionMethods:We chose four regions according to the criterion of water iodine in Shandong province:low iodine region(LI,<10?g/L),normal iodine region(NI,50?150?g/L),high iodine region(HI,150 ?300?g/L),excessive iodine region(EI,>300?g/L).Based on the stratified cluster sampling method,we selected 3?5 villages in each region and chose the subjects who meet the selection criteria.This investigation includes three parts:questionnaire,physical examinations and laboratory tests.Questionnaire is composed of basic information and 3 days 24 hour dietary questionnaire.Physical examinations are made up with height,weight and blood pressure.And laboratory tests include water iodine,urine iodine,blood lipid and blood rhelogy.3 days 24 hour dietary questionnaires were converted into excel tables using nutrition calculator V2.65.The other questionnaire and physical examination data were imported into Epidata3.1.And all statistical analysis was performed with SPSS 20.0.Results:1.The demographic characteristics of the objectsThere are 1984 effective questionnaires,including 409 in LI,325 in NI group and 478 in HI,and 772 EI.Men and women account for 37.30%and 62.70%respectively.The age distribution is negative skew in all regions.There is significant difference of junior diplomas and Occupations(P<0.05).And occupation is given priority to farmer in each regions.There is significant difference in smoking status(P<0.05).LI has the highest ratio of used to smoke among regions;NI has the highest ratio of no smoke,and lowest ratio of smoke;HI has the lowest ratio of no smoke and highest ratio of smoke;EI has the lowest ratio of used to smoke.There are no differences of gender,age and drinking status among regions.2.Nutrition investigationThe evaluation of nutrients consumptions,and the nutrient compliance rates(the rate of objects whose nutrients intake meeting the 80%of dietary nutrient RNI or AI,and less than UL)were made.The nutrient compliance rates of energy,protein,vitamin A,vitamin E,thiamine,nicotinic acid,vitamin C,calcium,phosphorus,potassium,magnesium,iron,zinc,selenium,copper,manganese and energy supply ratio of carbohydrates and fat are in varied regions are differents(P<0.05).And there is no significant difference in riboflavin,vitamin B6,vitamin B12,folic acid,sodium and iodine nutrient compliance rates in varied groups.3.Physical examinationsThere are no differences of height,weight,BMI index and systolic pressure among regions.But the diastolic pressure of NI is higher than LI,HI,and EI(P<0.05).4.Laboratory tests4.1 Water iodine and urine iodine in different regionsThe median of water iodine of LI,NI,HI,El is 93.10?g/L,235.60?g/L,291.50?g/L and 807.25?g/L respectively and there is significant difference of urine iodine among regions.According to the criterion WHO,UNICEF and ICCIDD made to assess population iodine nutrition with median urinary iodine,people of LI are short of iodine;the iodine intake in NI and HI are higher than iodine requirements but lower than excessive iodine standard;people live in excessive water iodine region overtake iodine.4.2 Blood lipid in different regionsThere are no differences of TG,HDL-CH and Apo B among regions.The values of TC in LI and NI are higher than that in HI and EI.The concentration of LDL-CH in LI is higher than that in NI and HI(P<0.05),while LDL-CH in EI is lowest among regions(P<0.05).The level of ApoA ? in EI is higher than that in LI and HI(P<0.05),and ApoA ? in NI is lowest among regions(P<0.05).The value of ApoA ?to ApoB in EI is higher than that in LI,NI and HI.4.3 Blood rheology in different regionsThere are no differences of HCT,?b-L?,and ?b-M? among regions.The level of?b-H? in HI and EI are higher than that in LI and NI(P<0.05).The concentration of?p in LI is higher than that in NI,HI,and EI(P<0.05).The erythrocyte rigidity index and erythrocyte deformation index in LI are lower than that in NI,HI and EI(P<0.05).The erythrocyte aggregation index and erythrocyte electrophoresis index in EI are lower than that in LI,NI,and HI(P<0.05).5.The multinomial logistic analysis of abnormal blood rheologyThe multinomial logistic analysis shows that the sex,age,diastolic pressure,water iodine,TG,TC,ApoA ?,ApoB,dietary vitamin A and dietary iron are the influencing factors of abnormal blood rheology.Men are more likely to get high ?b than women,but women are more likely to have low ?b than man.Age is the protective factor of low ?b-M?.With the diastolic pressure rising,the risk of high ?b increase.TG is the risk factor of high ?b-M? and high ?b-H?.With the level of TC comes up,the possibility for people to get ?b-H? goes down.ApoA ? is the protective factor of high ?b-L? and high ?b-M?.ApoB is the protective factor of low ?b-L? and low ?b-M?,as well as the risk factor of high ?b-L? and high ?b-M?.Dietary vitamin A is the protective factor of ?b-L? while dietary iron is the risk factor of ?b-L?.The possibility to get low ?b for people in low water iodine region is higher than that in normal water iodine region.And people in excessive water iodine region are less likely to have low ?b-H? than that in normal water iodine region.Conclusions:1.There are no differences of HCT,?b-L?,and ?b-M? among regions.The level of?b-H? in HI and El are higher than that in LI and NI.The concentration of ?pin LI is higher than that in NI,HI,and EI.The erythrocyte rigidity index and erythrocyte deformation index in LI are lower than that in NI,HI and EI.The erythrocyte aggregation index and erythrocyte electrophoresis index in EI are lower than that in LI,NI,and HI.2.The influencing factors of abnormal ?b are sex,age,diastolic pressure,water iodine,TG,TC,ApoA I,ApoB,dietary vitamin A and dietary iron.?b in men is higher than that in women.Age,diastolic pressure,TG,TC,ApoB and dietary iron are the risk factors of high ?b.ApoA I and dietary vitamin A are the protective factors of high ?b.3.Low water iodine could decrease ?b through increasing erythrocyte deformability,while excessive water iodine could reduce erythrocyte deformability or ApoA I and raise ?b.