| Objective:To determine whether the circulating estradiol?FSH levels are associated with cognitive function in perimenopausal and postmenopausal women.Methods:It is a cross-sectional study include 199 perimenopausal or postmenopausal women.Informations were collected using a standardized questionnaire.We assessed cognition function with the Montreal Cognitive Assessment.Circulating estradiol and FSH levels were obtained and all of the datas were analysed.Results:1.Higher scores of MoCA is associated with increasing quartiles of serum estradiol level,statistically significant can be find between groups(P<0.05),except Q3(E2=51.39-129.50 pmol/1)and Q4(E2=129.51-952.40 pmol/1).A significant decrease in the frequency of cognitive impairment(MoCA<26)was observed with increasing quartiles of serum estradiol level(P<0.001).2.Higher scores of MoCA is associated with decreasing quartiles of serum FSH level,women in Q1(FSH=0-35.38IU/L)have higher scores of MoCA than women in Q3 and Q4(P=0.014,0.000),women in Q2(FSH=35.39-59.65IU/L)have higher scores of MoCA than women in Q4(P=0.011).Increasing quartiles of FSH is associated with higher frequency of cognitive impairment.3.Menopause,personal income and educational levels were related to cognitive performance(P<0.05.After adjusting for age,marriage status,personal income,educational level and other potential confounders,higher estradiol levels were associated with better cognitive function(P<0.05).The frequency of cognitive impairment was decreased in participants with higher level of education(P<0.05).However,levels of FSH were unrelated to cognitive performance.Conclusions:Perimenopausal and postmenopausal women with higher levels of circulating estradiol are associated with lower risk of cognitive decline.This effect still exists after adjustment for age,marriage status,educational level,and other protential confounders.Our findings confirm the hypothesis that endogenous estradiols may have beneficial effects to cognitive function. |
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