| Objective:Through the early intervention program of traditional Chinese medicine "syndrome differentiation" to treat acute ischemic stroke,the follow-up evaluation and effect evaluation of early intervention program of "ischemic stroke" and "syndrome differentiation" were carried out.For the early intervention of traditional Chinese medicine program widely used in clinical provide a basis.Methods:In this study,prospective cohort study was used.The patients were admitted to hospitalized patients who received the standard of neurology in Hubei Province from March to February 2017.The patients were randomly divided into treatment group(recommended program)and control group(no recommended plan),the number of patients were 27 cases,20 cases.The two groups of patients were based on the standardized treatment of the "Guide"("China Acute Ischemic Stroke Diagnosis and Treatment Guide 2014"),the treatment group(select the recommended program)on the basis of standardized medical treatment,plus Xingnaojing injection vein Infusion,every 12 hours 1,continuous treatment of 7 to 10 days,while dialectical to the recipe of Chinese medicine particles.All patients included in the study were enrolled in the group for 3 days,for 7 days,for 10 days,for 14 days(or the day of discharge),30 ± 3 days,90 ± 3 days The The compliance and evaluation of the two groups were evaluated.Short-term effect assessment: On the 14 th day of admission or on the day of discharge,neurological deficits were assessed using the NIHSS score,and the daily living activity was evaluated using Bathel-Index,and the patient's self-health assessment was evaluated using PRO.Long-term effect assessment: the 30 th day,90 days of daily living ability "relative independence" as the main efficacy indicators,using the improved Rankin scale evaluation;daily living activity using Bathel-Index evaluation.The data obtained from the data analysis and the measurement data were tested by the normality test and the variance homogeneity test.The two samples were compared with the t test,and the paired t test was used before and after the comparison.The two samples were not compared with the conditional(Wilcoxon),compared to their own before and after the use of matching rank test(Wilcoxon).The comparison of the counting data was performed using a chi-square(X2)test.All the statistical tests were used bilateral test,set P<0.05 when there were statistical differences.And according to the blood before and after treatment + CRP,urine,electrocardiogram,liver function,renal function,coagulation and other comparative analysis of its safety.Results : 1.Before and after enrollment,the gender,age,compliance,neurological deficit score(NIHSS),daily living activity score(Barthel Index),neurological recovery status score(Modified Rankin Scale),the results suggest that the difference is statistically insignificant(P>0.05),comparable.2.Neurological deficit score(NIHSS): The NIHSS score of the control group was significantly lower than that of the control group at the 7th day and the 14 th day,and the difference was statistically significant(P<0.05).There was no significant difference in NIHSS score between the two groups(P>0.05),but there was no significant difference between the NIHSS score and the NIHSS score(P<0.05)The There was no significant difference in NIHSS scores between the two groups at the 7th day and the 14 th day(P>0.05).There was no significant difference in the NIHSS score between the two groups(P>0.05).However,the NIHSS score and the baseline difference in the treatment group were significantly higher than those in the control group on day 14 Statistical differences(P<0.05).3.Comparison of daily living activity(Barthel-Index,BI): There was no significant difference in BI index between the two groups(P>0.05),but the BI index scores of the two groups were significantly higher than those of the control group(P<0.05)(P<0.05).Compared with the control group,the BI index score of the treatment group was significantly higher than that of the control group(P<0.05).4.Comparison of neurological functional status(Modified Rankin scale)score: There was no significant difference between the two groups(P>0.05).However,the scores of the two groups were 30 days and 90 days after the group.The Rankin scale scores were(P<0.05).The difference was statistically significant(P <0.05).5.Patients reported a clinical outcome(PRO)comparison: There were no significant differences in the scores of PRO between the two groups(P>0.05),but the score of physiological function in the treatment group was improved,the difference was statistically significant(P<0.05).Conclusion : 1.Compared with the control group,the early intervention program of traditional Chinese medicine can significantly reduce the rate of neurological deficit in the acute phase of ischemic stroke patients and improve the recovery rate of neurological function in patients with ischemic stroke.The rehabilitation plays an important role.2.The long-term activities of daily living in patients with acute ischemic stroke have a significant advantage compared with the control group.3.Chinese medicine "disease card syndrome" early intervention program for the treatment of acute ischemic stroke is a relatively safe intervention,less adverse reactions,with good clinical compliance,can be widely used ischemic stroke acute phase. |
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