Clinical Research On The Role Of Interleukin-6 And Alkaline Phosphatase On The Severity Of Coronary Artery Disease

Background:The incidence and mortality of coronary atherosclerotic heart disease(CHD)is increasing year by year,which is a serious threat to human health.Atherosclerosis(Atherosclerosis,AS)plaque rupture and thrombosis is the pathogenesis of acute cardiovascular events.Early identification of vulnerable plaques that may be ruptured is an important means of screening for vulnerable patients to actively intervene in the process of acute cardiovascular events,and plaque stability has also become an important basis for efficacy evaluation.AS plaque from stable to vulnerable process involves inflammation,immune,metabolism,coagulation and other links.Studies have shown that inflammation is involved in thrombosis,but in the formation of thrombosis plaque does not rupture,but because of plaque surface erosion,ulcers,calcification nodules lead to plaque progression.At the same time,there is a small amount of calcification or punctate calcification in the vulnerable lesions.Therefore,we propose hypotheses that inflammatory factors,calcification factors,together contribute to plaque progression.The relationship between IL-6 and atherosclerosis has been more basic and clinical research.Studies have shown that IL-6(high-sensitive C-reactive protein,hs-CRP)can be used as an independent risk factor for predicting coronary heart disease.IL-6 is an important inflammatory indicator that indicates the development of inflammation and the relationship between predicting long-term cardiovascular risk events.ALP is closely related to calcification,and domestic and foreign studies focus on bone formation and liver-related diseases.Whether ALP is involved in the increase of plaque vulnerability,the clinical prospective study of inflammatory factors IL-6 and calcification factor ALP on the predictive value of acute coronary events and the correlation between them are not reported at home and abroad.,It is important to study the relationship between IL-6,ALP and coronary atherosclerotic heart disease and plaque stability,and to explore new intervention targets for coronary heart disease and plaque stabilityObjective:To evaluate the degree of coronary artery lesion by coronary angiography and Gensini score,which measures degree of arterial stenosis.The acute myocardial infarction(AMI),unstable angina pectoris(UAP),stable angina pectoris(stable angina pectoris,SAP)and control group,and to explore the role of serum IL-6 and ALP in predicting the degree of coronary artery lesion and acute coronary events.Method:60 patients with CHD diagnosed by coronary angiography(CAG)were enrolled in this study,including 20 patients with unstable angina pectoris(UAP),20 patients with acute myocardial infarction(AMI)and 20 patients with stable angina pectoris(SAP).Twenty patients with CAG showed no stenosis as a control group.Detailed records of patients with medical records,including general clinical data and biochemical indicators.The levels of serum IL-6 and ALP were measured by enzyme-linked immunosorbent assay(ELISA),and the levels of serum lipids and fasting blood glucose(GLU)were measured.Gensini score was used to analyze the correlation between the levels of IL-6 and ALP and Gensini in coronary artery lesion and correlation analysis.The statistical significance was set as P<0.05.Descriptive analysis was set as mean ± SD and Pearson correlation analysis.All computations were carried out with IBM SPSS 23.0 software.Results:1.The levels of IL-6 and ALP in AMI and UAP group were significantly higher than those in SAP group and control group(P<0.01).The serum levels of IL-6 and ALP in AMI group were significantly higher than those in UAP group(P.<0.05)2.Coronary heart disease group(SAP group + UAP group + AMI group)there was a significant positive correlation between ALP and Gensini scores in AMI group(r = 0.322,P<0.05 and r = 0.421,P<0.01).3.There was a significant positive correlation between ALP and Gensini scores in AMI group(r = 0.674,P<0.01)4.There was a significant positive correlation between IL-6 and Gensini scores in UAP group(r = 0.488,P<0.05).5.The levels of IL-6 and ALP in SAP group were not correlated with Gensini score.Conclusion:IL-6 and ALP levels were significantly higher in vulnerable patients,suggesting that IL-6 and ALP were closely related to plaque instability and rupture.The level of IL-6 and ALP in patients with coronary heart disease increased with the increase of Gensini score,indicating that it was positively correlated with coronary artery stenosis.The ALP level in the AMI group was positively correlated with the Gensini score,suggesting that ALP could be used as a new predictor of atherosclerotic plaque and a new target for treatment.It provides a convenient index for assessing the severity of coronary artery disease.And coronary artery stenosis was positively correlated,can be used to determine the severity of ACS predictive indicators.