Clinical Study On The Association Between Body Mass Index And Invasive Factors Of Papillary Thyroid Carcinoma

Purpose:Discuss the correlation between BMI and invasive factors of Thyroid papillary carcinoma.Methods:Collect the data of total 461 patients with thyroid papillary carcinoma of Shandong Province Hospital from 2011.1.1 to 2012.12.31 for retrospective analysis.Grouping all the patients into 3 groups reference the BMI standard of WHO:underweight(<18.5)?normal weight(18.5?24.9%)?overweight(>25.0).Stating the invasive factors of each groups including tumor size?TNM staging?tumor grade?single or multiple?extra-thyroidal invasion.In order to avoid statistical deviation,the underweight group was excluded of this analysis for the reason of its' small sample.Analyze the invasive factors of normal groups and overweight groups with the chi-square test.Statistical analysis was performed using SPSS version 19.0 software.When the P value<0.05,that is statistically significant.Analysis whether the correlation between BMI and invasive factors of thyroid papillary carcinoma exists or not.Results:A total of 461 patients with papillary thyroid cancer(106 males and 355 females)were enrolled in this study.Forty-seven patients(38.4%)had extra-thyroidal invasion.The number of patients with central area lymph node metastasis is 234,while there are 162 patients had lateral neck lymph node metastasis.138 patients(27.8%)had both central lymph nodes and lateral neck Lymph node metastasis.7 patients(1.5%)had distant metastases.192 patients(41.6%)had multiple lesions of papillary thyroid carcinoma.Forty-eight patients(32.1%)had postoperative pathology confirmed high TNM staging(Phase ? or ?).13 patients(2.8%)had vascular invasion.Compare the tumor diameter between the normal weight group and the overweight group:tumor diameter ?1cm and>1cm were 136(58.3%)and 97(41.7%)in the normal weight group while there were 102(47.0%)and 115(53.0%)in the overweight group,(P<0.05).Extra-thyroidal invasion:In the normal weight group,the number of patients had extra-thyroidal invasion was 64(27.5%),and other 169(72.5%)cases without extra-thyroidal invasion.The number of cases of extra-thyroidal invasion and non-extra-thyroidal invasion in the overweight group were 111(51.2%)and 106(48.8%),(P<0.001).The number of cancer(single or multiple):The number of single tumor was 142(60.9%)in the normal weight group,and 91(39.1%)cases with multiple tumors.The number of cases with multiple tumors was 118(54.4%),and the number of multiple tumors was 99(45.6%)in the overweight group,(P>0.05)TNM staging:In the normal weight group,173(74.2%)cases in the staging ? and?,60(25.8%)cases in the staging ? and ?.There were 132(60.8%)and 85(39.2%)cases in the overweight group,(P<0.05).Cervical lymph node metastasis:The number of patients with cervical lymph node metastasis was 124(53.2%)in the normal weight group,and other 109(46.8%)cases without cervical lymph node metastasis.There were 136(62.7%)and 81(37.3%)cases in the overweight group,(P<0.05).Conclusion:In patients with thyroid papillary carcinoma,high BMI values are associated with high tumor invasiveness(greater tumor diameter,extra-thyroidal invasion,tumor cervical lymph node metastasis,higher TNM staging),and other factor as cancer numbers(single or multiple)are not significantly correlated.It is necessary for patients who have high BMI values to keep regular follow up.More research needed to confirm this conclusion.