Morphology Of Cerebral Cortex In Schizophrenia Based On Multi-Center Magnetic Resonance Imaging

The magnetic resonance imaging (MRI) techniques are becoming a powerful tool to study brain science with its fast development, and promote the human to understand,protect and develop their own brain. Various brain image analysis technologies make people explore and study the brain from multiple angles. By morphological analysis on brain, people can understand its various structure information and discuss the possible change pattern of cerebral cortex in the process of disease and cognition, which helps to understand the pathogenesis of various brain disease deeply.Schizophrenia is a chronic persistent disease with high recurrence rate and high morbidity in psychiatry. Schizophrenia not only to the family and society to bring a heavy economic burden and the daily activities of the family, recreation, individual and family members of the mental health of a huge impact. There are many studies on schizophrenia at home and abroad, but the results are not consistent. Cortical morphological abnormalities in schizophrenic patients are almost all of the brain, frontal lobe, temporal lobe, parietal lobe, island leaves, occipital lobe, basal ganglia Cerebellum has been related to the study reported. The inconsistency of these findings led to the inability to find effective biological markers to explore the pathophysiologic mechanism of schizophrenia and to aid in clinical diagnosis and treatment. In this study,multidimensional schizophrenic patients with cortical morphology to find the study of schizophrenia effective biological markers. The main work is as follows:1.Through the study of cortical thickness in patients with multiple central schizophrenia, it was found that in the left lateral frontal gyrus, the left fusiform gyrus,the right frontal gyrus, the right frontal gyrus, the four brain regions, three central schizophrenia The patient's cortical thickness has decreased. Can focus on these four brain regions, as schizophrenia in patients with cortical morphology of the biological markers, and further explore the pathophysiology of schizophrenia.2.By examining the cortical volume of patients with multiple central schizophrenia,the cortical volume of the three central schizophrenic patients on the right dorsal anterior cingulate gyrus has been reduced. Can focus on this brain area, the brain area of cortical volume changes can be used as schizophrenia in patients with cortical morphology of biological markers.3.Through a study of cortical area and complexity in multiple central schizophrenia patients, three centers of schizophrenia did not have significant changes in the brain area,excluding the two morphological indicators from the cortical area and complexity to study schizophrenia.