Clinical Observation On Treatment Of Qi Of The Spleen Nourishing Qi And Blood Deficiency Syndrome Of Vascular Dementia

Objective:Using randomized controlled study method, observation of the clinical efficacy and safety of Yiqi Jianpi Yangxue method in the treatment of vascular dementia and to provide a clinical basis for Yiqi Jianpi Yangxue method in the treatment of vascular dementia.Method:This study adopts randomized, controlled principle, using a random number table method according to the ratio of 1:1, December 2013 to 2015 years 1 month during in Sichuan Province Hospital of traditional Chinese medicine/ Affiliated Hospital of Chengdu University of traditional Chinese medicine hospital and clinic patients with vascular dementia with Syndrome of deficiency of Qi and blood diagnosis standard of 60 cases of patients, divided into control group and treatment group,30 cases in each group.Nimodipine Tablets in the control group, the treatment group was treated with Nimodipine Tablets combined with Buzhong Yiqi Decoction and radix paeoniae alba, radix rehmanniae, leech, period of treatment in the two groups were treated for 12 weeks.Close observation of changes in condition of the patients before and 12 weeks of treatment, from Mini Mental State Scale (MMSE-R), daily life ability scale (ADL-R), TCM symptoms rating table related changes in the integral of each treatment protocol in improving cognitive function, improve the living ability, and TCM syndrome curative effect was evaluated.The observation results were analyzed by statistical software SPSS 19.0.Results:All the patients met the inclusion criteria, were divided into two groups, no rejection, shedding cases, and finally into the statistics of the cases were 60 cases.Comparison of therapeutic effect of MMSE score:Compared two groups of treatment at the end of the 12 week score before treatment of MMSE, group comparison for P< 0.05, the comparison between the two groups for P< 0.05, two groups of total efficiency comparison for P< 0.05, suggesting that treatment, the two groups in the improvement of patients' cognitive are effective. The treatment group was significantly better than the control group.Comparison of therapeutic effect of ADL score:Two groups after treatment, at the end of the 12 week treatment with before treatment, the scores of ADL score of within group and between group comparisons, the results for P< 0.05, suggested that the two groups to improve the ability of daily living were effective, the treatment group curative effect is obviously superior to the control group.TCM Syndrome Scale score comparison:The total effective rate of control group was 56.6%, the total effective rate of treatment group was 93.6%, there were significant differences between the two groups (P<0.01). The results indicated that the two groups were effective in improving the TCM syndrome, the curative effect of the treatment group was better than that of the control group.Drug safety aspects:The adverse reactions in the treatment of individual patients mainly include nausea and vomiting, skin itching, abdominal distension and so on, the two groups, the difference was not statistically significant.Conclusion:The study found that in the use of traditional and Western medicine treatment of this disease, combined with traditional Chinese medicine replenishing qi to invigorate the spleen nourishing therapy, in patients with vascular dementia syndromes of traditional Chinese medicine, daily life ability and cognitive function improvement aspect is superior to the single use of Western medicine and drug adverse reaction is not obvious.