Pharmaceutical Research Of Xuanlong Cough Particles

XuanLong cough particles were used in clinical of Teaching Hospital of Chengdu University of TCM for many years,composed by 9 flavor taste of traditional Chinese medicine,wich are radix scrophulariae, honey ephedra, earthworm, batryticated silkworm, radix stemonae,asters, dwarf lilyturf, fructus schisandrae, windproof Because XuanLong cough particles have the effect of nourishing the lung Yin,ventilating the lung,dispelling wind and relieving cough, they are used in clinical to treat the cough caused by Yin deficiency, wind injury lung, with internal cough asthma, etc. In this paper, we studied the pharmaceutical part of the preparations,mainly includes three aspects of the research content,which are preparation process research, quality standard research and accelerated stability research.Extraction process,in the part of preparation process research, mainly examines extraction process conditions of the ephedra decoction and combined decotion with other herbs such as radix scrophulariae. In ephedra decoction experiment,we investigate the suitable extracting time, using the single factor experiment method, with the contents of ephedrine hydrochloride(EPH) and pseudoephedrine hydrochloride(PSE), khabaro as evaluation index; in the part of combined extraction process, using the orthogonal experiment method, with comprehensive score of contents of ephedrine hydrochloride and pseudoephedrine hydrochloride and the dry paste yield as the evaluation index, we mainly examines the effects of the three factors like the extraction time, add water and extraction times on the extract to optimizing combined extraction conditions.According to the test results the ephedra extract 2 hours first, then with other herbs such as radix scrophulariae extract 2 times,each time 1 hour, by adding water 12 times of the herbs.In the study of enrichment and purification technology, mainly examines the thermal stability of EPH, PSE and khabarov, and based on the two indicators, optimize the technological parameters of purification. Results as follows:the condition of enrichment and purification of 60-80 ?, enriching to medicinal liquid ratio 0.75, centrifugal 30 min in 6000 r. min--1.In research of molding process, we take dextrin as forming agent, stevioside as taste masking agent, with ratio of pellet formation and dissolution as evaluation index, to select the suitable processing conditions.The final molding process conditions are as follows:when the liquid medicine is concentrated to the relative density of 1.20 to 1.30, dextrin will be added by the statement:dextrin (1:0. 52).After dried in an oven at 60-80 ?, the mixture is mashed to powder,which combined with 85% ethanol (including stevia 0.3%), to prepare particles.In the quality standard research and stability study, we have established method of TLC identification of figwort, ephedra, dwarf lilyturf, lumbricus yinpian and method of determination of harpagoside from sovereign medicine-radix scrophulariae and hydrochloride and pseudoephedrine hydrochloride from control drug-ephedra. From the test result of saccelerated stability for 6 months, we can find that the stability of the preparation is good.The initial formulation of the drug validity period is 1 year.