| BackgroundSelenium is an essential trace element that was discovered in 1817 by a Swedish chemist Berzelius. At that time it was known as the toxic mineral, it took more than 140 years until in 1957, its nutritional essentiality for humans were proved.As the thyroid has such a big influence on the total metabolism of human organism, it is wise to counteract the disorder as soon as possible. In accordance with literature and the newest research findings respectively one of the trigger factors of thyroid disease may be a selenium deficit. Selenium plays an important role in thyroid metabolism because of its participation in the iodine metabolism, as well as it neutralizes H2O2 and hence acts as oxidative agents for the thyroid. We hypothesized that selenium supply to the patients with thyroid disorder that can overcome the disease even in the short duration.ObjectivesTo observe the impact of selenium on the antibodies concentration of autoimmune thyroiditis and to explore the mechanism of selenium supplemented with thyroid diseases. Hypothyroidism group is compared with control group of hypothyroidism group and hyperthyroidism group is compared with the control group of hyperthyroidism group.MethodsObservation and clinical diagnosis of patients with autoimmune thyroiditis were divided into two groups:Group A (28 cases) with the diagnosis of hypothyroidism; Group B (18 cases) were patients diagnosed with hyperthyroidism. A group of patients were randomly divided into two subgroups - subgroup HA (14 cases) were provided levothyroxine with selenium; and Subgroup CA (14 cases) control subgroup for subgroup HA, only levothyroxine. Group B (18 cases) were also randomly divided into two subgroups-subgroup HB (7 cases) received methimazole with selenium; and subgroup CB group (11cases), control subgroup for HB. The levels of FT3, FT4, TSH, TGAb and TPOAb were measured, and the changes of these indexes were observed after selenium supplementation after 3 months exactly.ResultsIn group A, subgroup HA, after three months, TPOAb is decreased from 394.33 (170.636,726.27) to 134.32(22.87,529.00) with the P value<0.05 and TGAb from 446.86(132.82,1414.34) to 151.34(57.84,967.63) with the P value<0.05. Thyroid function test in the serum has not statically increased or decreased as FT3 is 2.29(1.78,2.72) and 2.37(2.26,2.60) with P value>0.05; FT4 is 14.23(10.44,15.49) and 11.99(10.64,13.73) with P value>0.05;and TSH is 3.81(1.86,9.38) and 2.15(1.42,9.77) with P value>0.05.In the control subgroup CA, neither TPOAb nor TGAb shows the statically difference, serum thyroid function test are also not statically significant.After 3 months of study period, in group B, subgroup HB, TPOAb is statically decreased from 332.17(117.19,447.85) to 234.86(57.69,303.29) with P value<0.05 and TGAb from 313.35(19.09,496.99) to 150.38(11.24,445.65) with the P value<0.05. Thyroid function test in the serum are not statically increased or decreased as FT3 2.39(2.01,2.68) and 2.51(2.17,3.59) with the P value>0.05; FT413.05(12.27,14.97) and 11.29(9.74,13.81) with P value>0.05, though the values are not statically decreased but it is decreased individually it may be due to the small numbers of participants; and TSH 1.85(0.87,2.67) and 1.85(0.68,3.21) with P value>0.05.In the control subgroup CB, neither TPOAb nor TGAb shows the statically difference. Thyroid function test are also not statically significant.ConclusionsSupplementation of selenium can decrease severity of the autoimmune diseases in the patients either with hyperthyroidism or hypothyroidism which is reflected by significantly decrease of TPOAb and TGAb. |
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