The Clinical Research The Pathogens Distribution Of Children With Lower Respiratory Tract Infection

Objective To investigate children's lower respiratory infection pathogenic bacteria distribution and drug resistanceMethods Collecting the sputum specimens of 8159 cases with lower respiratory tract infections from 2010 to 2014 cultivate and detect the positive specimens and analysis the drug susceptibilityResults 8159 patients with lower respiratory tract infection in patients with sputum culture positive cases, gram positive bacteria accounted for 301 cases, in which the distribution of more is Streptococcus pneumoniae (218), golden yellow staphylococcus (59); gram negative bacteria accounted for 1103 patients, of which the distribution of more pneumonia Klebsiella pneumoniae (262 cases), Escherichia coli (209 cases), Pseudomonas aeruginosa bacteria (133), Bowman does not move bacillus (129 cases), Enterobacter coli (120 cases), acid producing Klebsiella pneumoniae (53 cases), flu bloodthirsty bacillus (45 cases), fungi (49 cases), in which the distribution of more is Candida albicans (37 cases). Streptococcus pneumoniae resistance rate higher antibiotic erythromycin 212 (97.25%), clindamycin 178 (81.65%), azithromycin 172 (78.90%) and the high rate of drug resistance of Staphylococcus aureus with penicillin G 52 (88.14%) and erythromycin 35 (59.32%). Gram negative bacteria:Klebsiella pneumoniae is a higher rate of 151 (57.63%), cefazolin, cefuroxime, ceftnaxone (148 56.49) 141 (53.82%), SMZ-TMP 121 (46.18%), ampicillin sulbactam 107 (40.84); the drug resistance rate of Pseudomonas aeruginosa was 126 higher cefuroxime (94.74%) 125, SMZ-TMP (94%), cefotetan 124 (93.23%),123 (92.48%), cefazolin, ampicillin sulbactam, ceftriaxone (123 92.48%) 122 (91.73%); Escherichia coli resistance rate is 139 (66.51%) of cefuroxime and ceftriaxone (134,64.11%) 131 cefazolin (62.68%), SMZ-TMP (60.29%); 126 Bauman Acinetobacter resistance rate is 126 (96.67%), cefuroxime, cefazolin (96.12%),124 (96.12%) 124 cefotetan; Enterobacter cloacae resistance rate is higher Cefazolin 93.33%(112), cefuroxime 112 (93.33%), cefotaxime cefotetan 110 (91.67%); acid Klebsiella resistant high rate is cefazolin 50 (94.34%). The distribution of pathogenic bacteria varies with age. This study showed that 28 days-14 years old children were in negative bacteria accounted for the majority; 28 days to 6 months for children with negative bacteria distribution more; 7 months to 6 years old children with Streptococcus pneumoniae was more, still with negative bacteria accounted for the majority, at the age of 2 to 6 years old in Streptococcus pneumoniae (46 cases) is relatively more, mostly negative bacteria; 7 to 14 years in sputum culture positive rate is low. 2010 to 2014 was selected in the number of cases than in previous years is relatively stable, sputum culture positive rate increased year by year; flora distribution basically stable, a slight increase in the distribution of flora, the number of some rare flora showed increasing trend, negative bacteria flora and number as the time delay increases significantly.Conclusion the commonly used antibiotic resistance is common in clinic, which can be reasonably selected according to the condition of the disease and the drug sensitivity.1 the number of pediatric pathogens in our hospital was significantly increased than in previous years, the proportion of negative bacteria increased compared with previous years, the proportion of positive bacteria decreased compared with previous years; gram negative bacteria still accounted for a large proportion.2. Sputum culture positive Common Gram positive bacteria and gram negative bacteria resistance rate than in previous years has increased, the drug resistance of gram negative bacteria rate than in previous years increased more significantly; the higher levels of antibiotic and its nibbe drug rate lower.3.28 days-1 years old with gram-negative bacteria for the majority,2 years old ?6 years old with gram-negative bacteria slightly more than 2 years old children's sputum culture positive rate is higher.4.2010 years ?2014 years, the number of selected cases is relatively stable, the positive rate of sputum culture in the overall rise, the proportion of gram negative bacteria significantly more than the positive bacteria.