Analysis About Clinical Featuresof 344 Casesof Brucellosis

Objective The aim of this study is to discussion the epidemiology, clinical features, laboratorytests and treatment of Brucellosis,and to summary the experience of diagnosis and treatment.Methods This is a retrospective descriptive study(from January 2010 up to May 2015), which are composed of 344 patients from Ningxia Medical University General Hospital.We have analysised retrospectively the epidemiological data, clinical features, laboratory examination and treatment of these patients.Results The number of patients with brucellosis in Ningxia Medical University Ge neral Hospital were increasing year by year past five years.The patients increased by 2.0% in 2011 than in 2010,1.09% in 2012 than in 2011,0.35% in 2013 than in 2012,a nd 1.09% in 2014 than in 2013.The patients appeared in every month,March to Augus t was the peak season.Each area of Ningxia had the Brucellosis patients. The aquacult ure developed regions have a high incidence,but the trend had gradually spread to urb an areas.Most patients were males, the ratio between males and females is 2.47:1.The most patients were 30 to 70 years old,and the mean age was 41.62±14.2y.Patients m ostly were farmers and herdsmen(62.50%),there were occupational distribution features.The patients who had contacted with sheep account for 63.66%.The clinical manifestati ons of Brucellosis were complex and diverse.The most patients had fever and joint pai n,some patients accompanied by sweating,fatigue,anorexia and chills.A few patients had some symptoms,such as headaches,nausea,vomiting,cough,sputum,chest tightness,shortne ss of breath,liver and spleen enlargement, testicular swelling and pain.Few patients had a rash,convulsions,neck lymph nodes.The complications for the patients accounted for 38.08%,and brucellosis spondylitis accounted for 82.44% among these patients.The dep artment that patient visited firstly were diverse.SAT positive could diagnose Brucellosis,and the blood culture positive rate was 49.26%.The results were brucella melitensis.We found that the blood cells and liver function were abnormal,and the erythrocyte sedi mentation rate,C- reactive protein,procalcitonin,lipopolysaccharide were foung rising.The main choice of treatment was quinolones,rifampicin and doxycycline, parts of patients who combined brucellosis spondylitis had a surgery.All the patients were cured.Conclusion The main clinical manifestationsof brucellosiswere fever,bone and joint disease,hepatosplenomegaly.the blood culture positive rate was 49.26%,the results were brucella melitensis.Spondylitis was the main complication.The Infection and orthopedics department accounted for the most of departments that patient visited firstly.Most patients who had received treatment of quinolones,rifampicin and doxycycline could resume.