| Purpose Retinal hypoxia is believed to be involved in various eye diseases. Among them are retinal vessel occlusions, retinal detachment and glaucoma etc. Oxymap T1 Retinal Oxymeter(Oxymap, Reykjavik, Iceland) is a noninvasive device specifically to measure retinal blood oxygen saturation and vessels diameter. The Oxymap Analyzer software analyzes the images from the oximeter and automatically returns relative data. The aims of this thesis are to use this retinal oximeter to test whether retinal vessel oxygen saturation and vessels diameter are changed by DR and VKH.Method37 patients referred for specialist evaluation of diabetic retinopathy and 15 normal control persons,14 patients of VKH and 10 normal control persons were subjected to retinal oximetry respectively. The oxygen saturation and vessels diameter in arterioles and venules was compared between these groups.Results1. Oxygen saturation in retinal arterioles was 94.28±7.01 % in patients with NPDR,97.44±7.13 % in PDR, 94.94±7.88 % in PDR after laser and 92.94±6.44 % in healthy subjects. Retinal arterioles oxygen saturation was higher in eyes with PDR than control group(t=3.896,P=0.0026).2. Oxygen saturation in retinal venules was 60.84±4.04 % in patients with NPDR,65.63±5.19 % in PDR, 61.06±4.41 % in PDR after laser and 59.31±5.38 % in healthy subjects. Retinal venules oxygen saturation was higher in eyes with PDR than control group(t=4.69,P<0.0001), NPDR group(t=3.63,P=0.0005), PDR after laser group(t=2.84,P=0.0116).3. The arteriovenous difference was 33.66±4.74 % in patients with NPDR,34.30±4.37 % in PDR, 31.22±4.50 % in PDR after laser and 35.85±6.58 % in healthy subjects. The arteriovenous difference was not significantly different between groups.4. The mean arteriolar diameter was 11.95±1.67 pixels in patients with NPDR,12.32±2.68 pixels in PDR, 12.37±2.29 pixels in PDR after laser and 11.84±2.34 pixels in healthy subjects. Mean arteriolar diameter was not significantly different between groups.5. The mean venules diameter was 15.78±2.26 pixels in patients with NPDR,16.14±2.94 pixels in PDR, 15.94±3.65 pixels in PDR after laser and 15.17±3.64 pixels in healthy subjects. Mean venules diameter was not significantly different between groups.6. Oxygen saturation in retinal arterioles was 90.87±5.81 % in patients with VKH,92.19±5.08 % in healthy subjects. Oxygen saturation in retinal arterioles was not significantly different between groups.7. Oxygen saturation in retinal venules was 54.34±8.05 % in patients with VKH,60.07±7.91 % in healthy subjects. Retinal venules oxygen saturation the control group was significantly higher than that in the VKH group(t=2.443, P=0.017).8. The arteriovenous difference was 38.54±7.16 % in patients with VKH and36.28±6.09 % in healthy subjects. The arteriovenous difference was not significantly different between groups.9. The mean arteriolar diameter was 11.04±1.94 pixels in patients with VKH and12.14±2.11 pixels in healthy subjects. The mean arteriolar diameter in control group was significantly higher than that in the VKH group(t=2.406, P=0.018)10. The mean venules diameter was 14.80±3.46 pixels in patients with VKH and14.79±3.58 pixels in healthy subjects. Mean venules diameter was not significantly different between groups.Conclusions1. Oxygen saturation in retinal arterioles and venules were higher in eyes with PDR.Oxygen saturation in retinal venules was lower in eyes with VKH and the mean arteriolar diameter is lower than healthy group2. The Oxymap T1 Retinal Oxymeter can effective measure the blood oxygen saturation and diameter of retinal vascular, this might improve the understanding of the pathophysiology of the DR and VKH. |
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