The Preliminary Study Of Imaging Examination In Lymphatic Disease/Hematopathy Diagnosis And Treatment

Objective:In order to retrospectively evaluate the CT findings of abdominal fungal infection in immunocompromised patients who get blood disease.Materials and methods: Collecting 17 patients who got blood diseaes and were provened or probabled abdominal fungal infection in last 2 years.CT scans were reviewed with regard to the sites, number, morphologic appearance,attenuation, and the contrast enhancement patterns of the lesions in 17 patients, include 8 females and 9 males,mean age 24.5±16.8 years; range, 3–49 years.And meanwhile,medical records were also reviewed to determine each patient's clinical status and outcome.Results: ALL patients were immunocompromised state: 11 patients in acute myeloid leukemia(5 M2 types and 6 M5types) and 4patients in acute lymphoblastic leukemia received chemotherapy immunosuppressive therapy, 1 patient received immunosuppressive therapy after bone marrow transplantation for severe aplastic anemia,1 patient received no therapy for very severe aplastic anemia.Fungal infection involved liver, spleen,kidneys and gastrointestinal tract.CT demonstrated solid organ or bowel infarction or perforation secondary to vascular thrombosis,multiple low-attenuating lesions of solid organs presenting as abscesses.Conclusion: Familiarity with findings commonly presenting on CT,may facilitate the diagnosis of rare and fatal abdominal fungal infection.Objective: To analyze the differences of the size and the shape of lymph nodes between GCB type and non-GCB type diffuse large B cell lymphoma,and try to make the differential diagnosis. Methods:Collected a total of 46 cases from 2008 to 2014, in which patients had a clear pathological diagnosis of DLBCL and clear immunohistochemical tumble types, and complete image data,recorded the bilateral neck, bilateral jaws,armpit on both sides, bilateral supraclavicular fossa, bilateral groin,and abdominal cavity each side two largest vertical diameter of the product and long diameterd/short dianeterd(L/S)of lymph nodes.We performed unpaired T test and Mann- Whiteny U test to every part and whole body vertical diameter of product and L/S from GCB and non- GCB groups,and then compared by mean differences of groups which was statistically significant,and subsequently drew ROC curve. Results: The vertical diameter of the product:whole body of GCB type: 0.88(0.31,1.00)cm2; whole body of non-GCB type: 0.84(0.44,1.44)cm2;the neck group of GCB type: 1.05(0.47,1.13)cm2;the neck group of non-GCB type: 1.14(0.61,4.00)cm2;the groin group of GCB type: 0.38±0.26cm2;the groin group of non-GCB type: 0.72(0.44,0.98)cm2.The vertical diameter of products of the lymph nodes between GCB type and non-GCB type DLBCL are statistically significant in whole body(P=0.002),bilateral neck(P=0.034)and bilateral groin(P=0.002).ROC curve measured threshold:whole body:0.490cm2, bilateral neck:0.490cm2 and bilateral groin:0.952cm2.And the vertical diameter of products in,armpit on both sides, bilateral jaws,bilateral supraclavicular fossa and abdominal cavity are not statistically significant(P>0.05).L/S:Whole body of GCB type:1.91±0.71;whole body of non-GCb type:2.19±0.85; armpit on both sides group of GCB type:1.79±0.22; armpit on both sides group of non-GCB type:2.28±0.77;bilateral jaws group of GCB type:1.62±0.25; bilateral jaws group of non-GCB type:1.90±0.55. The L/S of the lymph nodes between GCB type and non-GCB type DLBCL are statistically significant in whole body(P=0.012), armpit on both sides(P=0.042)and bilateral jaws(P=0.033).ROC curve measured threshold:whole body:1.845, armpit on both sides:2.055,diagnostic significance level of bilateral jaws higher than 0.05.And the L/S in bilateral neck,bilateral groin,bilateral supraclavicular fossa and abdominal cavity are not statistically significant(P>0.05) Conclusions: In patients with DLBCL in non-GCB type,lymph nodes are generally larger than that of the GCB type, mainly in bilateral neck and bilateral groin,which can provide reference for the differential diagnosis;the malignant degrees in non-GCB type are lower than that of the GCB type,mainly in armpit on both side and bilateral jaws,and the data of the armpit on both side can provide reference for the differential diagnosis.