Clinical Significance Of Serum Intermedin In Patient With Acute Coronary Syndrome

Objective:To evaluate the serum content of intermedin(IMD) in patients with acute coronary syndrome(ACS) and to investigate the relationship between the IMD levels and severity of coronary artery stenosis and its clinical significance.Methods:The 55 acute coronary syndrome patients(ACS group, n=55) were enrolled in this study. Healthy individuals were as the control group(n=30).The serum levels of IMD and hs-CRP were determined by enzyme-linked immunosorbent assay. The severity of coronary artery stenosis for patients with ACS was measured by coronary angiography and expressed by the sum of Gensini scores. The correlation of IMD with the severity of coronary artery stenosis were analyzed with Pearson correlation analysis.Results:Serum IMD and hs-CRP levels were markedly higher in ACS patients than that in controls(both P< 0. 01). The increased serum IMD were positively correlated with Gensini scores(r=0.872,P< 0. 01). Serum IMD levels was positively correlated with hs-CRP(r=0.650,P< 0. 01).Conclusion:Plasma IMD levels were increased in patients with ACS, and associated with the severity of coronary artery stenosis, Cardio-protective effects of IMD is due to the inhibition of inflammatory, it can be a valuable biomarker in the diagnosis and assessment of ACS.