The Significance Of C-reactive Protein In Progression Of Patients With Chronic Hepatitis B

Objective: The aim of this study was to explore the potential role of serum C-reactive protein(CRP) in the pathogenic process of chronic hepatitis B,Understand the value of CRP in diagnosis of liver cirrhosis.Methods: July 2011 to May 2015 in Liver disease of General Hospital of Ningxia Medical University outpatient and hospitalization diagnosis of patients with CHB patients treated first as the research object, In addition, we choice healthy physical examination from the medical center as a control over the same period. All subjects were dawn fasting state, the peripheral venous blood collected 5 ml, after centrifuged and cryopreservation waiting for inspection. All patients received the concentrations of serum CRP, Hepatitis B sero-markers, serum HBV-DNA loads, liver function parameters and liver stiffness were measured, and in which part patients undertaken liver biopsy and immunohistochemistry analysis. Statistical analysis was conducted at last.Results: A total of 380 patients with CHB and 47 cases of healthy controls were included in the study. Serum CRP concentration in patients with the chronic hepatitis B(2.38 ± 5.52) was significantly higher than healthy controls(0.60 ± 0.53), P<0.05. Serum CRP concentration is correlated with liver function parameters(ALT, AST, TBIL), HBV-DNA loads and liver stiffness(r =0.446, 0.351, 0.485, 0.372, 0.4). Serum CRP concentration was significantly correlated with the severity of liver damage, HBV-DNA, Liver stiffness and the grading of fibrosis(r = 0.32,0.367,0.336 and 0.327, respectively). The area under ROC curve in fibrosis S4 and S3 is 0.826 and 0.78. The sensitivity and specificity of CRP for fibrosis S3 and S4 diagnosis were81.8%, 80% and73.4%, 76.2% respectively(cut off: 1.01mg/ml, 1.11mg/l).Conclusion: C-reactive Protein are associated with HBV replication, liver damage and fibrosis in patients with chronic hepatitis B, and serum C-reactive Protein may be a marker for diagnosing significant fibrosis in patients with chronic hepatitis B, and can reflect the severity of liver damage.