Study On Preparation Technology Of Lorcaserin Hydrochloride

Objective The synthesis method of lorcaserin hydrochloride will be studied, and the industrialized production will be obtained.Methods Lorcaserin hydrochloride was synthesized from 2-(4-Chlorophenyl)ethylamine through five steps including acylation, Friedel-crafts alkylation, amide reduction, chiral resolution and salifying.Results The preparation technology of lorcaserin hydrochloride was complished and the preparation technology was optimized. The taget compound was acquired and the total yield is 15.2%. The structures of intermediates had been established by MS, 1H-NMR, 13C-NMR. The structure of taget compound had been established by MS, NMR, IR and the purity had been determined by HPLC.Conclusions The obtained preparation technology of lorcaserin hydrochloride possess many advantages such as easily available raw materials, controllable reaction conditions and easy operation. This preparation technology lays a foundation for industrialized production of lorcaserin hydrochloride.