A Meta-analysis Of The Association Between The PTPN22 C1858T Polymorphism And Systemic Lupus Erythematosus

Objective: To explore the association between protein tyrosine phosphatase nonreceptor 22(PTPN22) C1858 T polymorphism and the risk of systemic lupus erythematosus(SLE) by meta-analysis.Methods: Systematic searches of Pubmed, Embase, Chinese National Knowledge Infrastructure(CNKI), Wanfang Database and Chinese Biomedical Database(CBMDisc) until February 17 th,2016 were performed to collect the published data on case-control study of PTPN22 C1858 T polymorphism and susceptibility of systemic lupus erythematosus. According to the inclusion and exclusion criteria, data were screened and extracted. We evaluated the quality of the included studies using the Newcastle-Ottawa Scale(NOS). Meta-analysis was conducted by Stata 12.0 software, using odds ratio(OR) and 95% confidence interval(95%CI) as the combined effects to evaluate to association between PTPN22 C1858 T polymorphism and systemic lupus erythematosus. Publication bias was judged by funnel plot and Egger's test. Sensitivity analysis was performed to estimate the stability of the results. Results: A total of 16 studies involving 3143 cases and 6980 controls were included in this meta-analysis of PTPN22 C1858 T gene polymorphism associated with SLE. The overall estimates showed a significant association between PTPN22 C1858 T polymorphism and risk of SLE under all genetic models(allele model : OR=1.64,95%CI=1.41-1.91;dominant model OR=1.60, 95%CI=1.42-1.81; recessive model OR=2.03, 95%CI=1.35-3.05;homozygote model OR=2.20, 95%CI=1.46-3.32; heterozygote model OR=1.57,95%CI=1.39-1.77). Subgroup meta-analysis displayed significant association between PTPN22 C1858 T polymorphism and susceptibility of SLE patients with the ethnicity of European,Spanish and Arabic, while no evidence showed this association with Asian SLE patients. Furthermore, this gene polymorphism may increase the risk of renal involvement in SLE patients(dominant model OR=1.65,95%CI=1.19-2.30). Conclusion: This meta-analysis showed that the PTPN22 C1858 T gene polymorphism is correlated with the susceptibility of SLE. Moreover, this gene polymorphism may increase the risk of renal involvement in SLE patients.