Effect Of Dexmedetomidine On The Efficacy Of Postoperative Patient-control Intravenous Analgesia Butorphanol Consumption In Patients Undergoing Gynecological Operation

Objective To evaluate the effect of dexmedetomidine on the efficacy of postoperative patient-control intravenous analgesia butorphanol consumption in patients undergoing gynecological operation.Methods Eighty ASA?or? patients scheduled for gynecological operation under general anesthesia were randomly divided into two groups(n=40 each) :DEX group(group D) and control group(group C).Patients in group D were received Dex 0.6?g·kg-1·h-1after the induction of anesthesia with laryngeal mask airway intubation and it wouldn,t stop until 40 minutes before the end of the operation. The corresponding volume of normal saline was injected in C group. Both groups received patient-control intravenous analgesia( PCIA)after operation:butorphanol 10 mg in 100 ml saline with ondansetron8 mg,background dose was 2 ml/h,the controlled dose was 2 ml,the lock time was 15 min.Patients,general information, operation time, extubation time and recovery room total time were recorded respectively. The scores of VAS, PCA pressing times, the cumulative consumption of butorphanol were recorded 1h, 2h, 6h and 24 h after the operation respectively. The occurrence of nausea, vomiting,hypotension, vertigo and pruritus were recorded for 24 h. Results There was no significant difference between the two groups of general situation(P >0.05). The difference of the VAS T1-T4 scores between the two groups were not statistically significant(P >0.05). After operation, D group were less than the control group about the PCA pressing times and there was a significant difference between the two groups.Butorphanol consumption of group D was significantly lower than group C(P<0.01). The incidence of adverse reactions after surgery of group D was lower than group C(p<0.05). Conclusion 0.6?g·kg-1· h-1dexmedetomidine intraveneous infusion can reduce the incidence of nausea and vomiting and shivering after general anesthesia and the consumption of postoperative 24 h analgesia of butorphanol,meanwhile enhance the analgesic effect without increasing the incidence of adverse reactions.