The Correlation Low-dose Pelvic Irradiation Zone Volume Of Cervical Cancer Post-Operation IMRT And Hematological Toxicity

Objective : To analyze the correlation low dose pelvic irradiation zone volume of cervical cancer postoperative intensity modulated radiation therapy(IMRT) and systemic hematologic toxicity. And to discuss the clinical value of the low dose pelvic irradiation dose limiting of IMRT.Methods:From September 2009 to October 2015, the 125 cervical cancer patients who were underwent postoperative IMRT with FIGO Ib-IIb were retrospectively analyzed. To Collect the minimum of WBC, NEU, LEU, HB, PLT for the first time before radiotherapy, during radiotherapy and after radiotherapy within 3 months and apply dose-volume histogram(DVH) to obtain the dose-volume parameter, such as V5, V10, V20. Hematologic toxicity were evaluated according to Radiation Therapy Oncolgy Group(RTOG) criteria.Results:V10, V20 were the independent factors of the Grade2 of Leukopenia and neutropenia(V10: P = 0.008 and P = 0.002; V20: P = 0.024 and P = 0.019); And then the V10 was independent factor of Grade 3 lymphopenia(P = 0.01). Respectively,while V10> 86%, V20> 73% and V10> 88%, V20> 73%, grade 2 leukopenia(V10: P<0.01; V20: P <0.01) and/or grade 2 neutrophils(V10: P <0.01; V20: P <0.01) may occur more often while V10> 80%, grade 3 lymphocytopenia may occur more often(P<0.01).Conclusion : To limit the irradiation volume of V10 and V20 of cervical cancer patients with postoperative IMRT can significantly, reduce their hematological toxicity has clinical significance.