Analysis Of Clinical Features Of Human Metapneumovirus And Human Bocavirus Infection Among Children With Acute Respiratory Tract Infections In Taiyuan, China

Objective:To investigate the status of Human Metapneumovirus(h MPV) and Human Bocavirus(HBo V) infection in children with acute respiratory tract infections(ARTIs) in Taiyuan, to analyze epidemiological and clinical characteristics of h MPV and HBo V, providing guidance for the prevention and treatment of h MPV and HBo V infection.Methods:549 Pharyngeal swab specimens were collected from children with ARTIs from November 2012 to May 2013 and November 2013 to May 2014 in shanxi provincial people's hospital, These patients were outpatients or inpatients. h MPV was tested by real-time fluorescent quantitative-reverse transcription-PCR(FQ-RT-PCR), and HBo V was detected using real-time fluorescent quantitative PCR(FQ-PCR). Analysis of the epidmiological and clinical features among children with ARTIs caused by h MPV and HBo V.Results:Among 549 samples, 56 specimens had evidenced of h MPV infection, 15 specimens had evidenced of HBo V, The positive rate of h MPV and HBo V was 10.2% and 2.7%,respectively. The detection rate of h MPV and HBo V in November 2012 to May 2013 was12.3%and 2.0%, respectively, November 2013 to May 2014 was 6.5% and 4.0%,respectively. The difference of h MPV positive rate was statistically significant in the two time(P<0.05), while HBo V was not(P>0.05). In different months, The detection rates of h MPV and HBo V showed no statistical difference(P>0.05). The patient age of h MPV and HBo V with highest positive rates were less than two years old(P<0.0125). There were no statistical significance in h MPV and HBo V detection rates between different gender groups. Main clinical manifestations of hMPV and HBo V positive patients for fever,coughing, wheezing, catarrh symptoms, pulmonary rales and radiographic changes in the lungs. The h MPV positive rate was highest in children with asthmatic bronchitis or bronchiolitis, and there was no statistical significance in these two disease(P>0.0063). The detection rate of HBo V showed no statistical difference in different disease(P>0.05).Conclusions:Our findings suggested that some of children with ARTIs in Taiyuan area are related to h MPV and HBo V Infection, h MPV is one of the important pathogens in children with wheezing in Taiyuan. The infection rates of h MPV and HBo V showed no difference in different months of winer and spring, Infection of h MPV and HBo V were common in children aged <2 years old, There showed no difference of h MPV and HBo V infection in gender.Main clinical manifestations of h MPV and HBo V positive patients for fever,coughing, wheezing, catarrh symptoms, pulmonary rales and radiographic changes in the lungs.