Protective Effect Of Metabolic Surgery On The Injury Of Rat Pancreatic Islets Induced By Streptozocin

Objectives To investigate the protective effect of metabolic surgery on the pancreatic injury induced by STZ in rats.Methods 50 rats were randomly divided into five groups:A normal control group,B stzinjured group,C surgery group, D surgery-injured group,E injured-surgery group,rats of A do not do any processing,The B were induced via intraperitoneal injection of STZ at days 7, The C underwent duodenal jejunal bypass surgery at days 1.The D were induced at days 7and underwent surgery at days 14.The E were underwent surgery at days 1 and were induced at days 7.Non-fasting blood glucose, OGTT, plasma C peptide and TNF was measured.Results At 7th day after injection of STZ, blood glucose of B,D,E groups was higher than the A group's(P<0.05) while there plasma C peptide were lower and TNF were higher than normal control group's(P<0.05).there Oral glucose tolerance were worse than the A group's. Islet pathologic injury of B,D,E groups appeared more serious than the A group's.There was no significant change of postoperative blood glucose(P>0.05),plasma C peptide(P>0.05),TNF(P>0.05) between D and B. Islet pathologic injury of B appeared as serious as D.Oral glucose tolerance was as bad as D.Blood glucose level of E group was lower than D(P<0.05), and the plasma c peptide waw higher than D(P<0.05), the TNF of E wae lowee than D(P<0.05). Oral glucose tolerance of E was batter than D. The islet pathologic injury appeared more batter than D.Conclusions metabolic surgery has a protective effect on the injury of pancreatic injury.The mechanism may be related to the inhibition of the inflammatory response of the pancreas by metabolic surgery.