Clinicopathological And Prognostic Features Of Steatohepatitic Hepatocellular Carcinoma

Objective:To analyze clinicopathological and prognostic features of steatohepatitic hepatocellular carcinoma(SH-HCC), and investigate the clinicopathological significance of steatohepatitic features in hepatocellular carcinomas.Methods:The clinical and pathological data were collected from 308 HCC patients undergoing curative resection in the First Affiliated Hospital of Fujian Medical University and Mengchao Hepatobiliary Hospital of Fujian Medical University from January 1, 2010 to December 31, 2012. Among these patients, 42 patients were SH-HCC, and 266 patients were used as non-SH-HCC. The time of followed-up terminated at December 31, 2015. The clinical and pathological data were analyzed by SPSS22.0 software package. Categorical variables were compared with chi-square test and quantitative variables were compared using student’s t-test. Overall and disease-free survival curves were generated using the Kaplan–Meier method and compared using the log-rank test. P<0.05 was considered as statistically significant.Results:Patients with SH-HCC were characterized by a higher frequency of diabetes and hypertension than those with non-SH-HCC(P < 0.05). The background liver of SH-HCC patients showed steatosis more frequently(P < 0.05). The 1-, 2- and 3-years disease-free survival rates of patients with SH- HCC were 42.9%, 24.3%, 15.8%, and the median disease-free survival was 12 months; The 1-, 2- and 3-years disease-free survival rates of patients with non-SH-HCC were 55.3%, 31.4%, 18.5%, and the median disease-free survival was 14 months. There was no significant difference in disease-free survival between the two groups(P>0.05). The 1-, 3- and 5 years overall survival rates of patients with SH- HCC were 83.3%、64.1%、40.5%, and the median overall survival was 39 months; The 1-, 3- and 5 years overall survival rates of patients with non-SH-SHCC were 86.4%、61.7%、37.3%, and the median overall survival was 48 months. There was no significant difference in overall survival between the two groups(P>0.05).Conclusions:1. SH-HCC was strongly associated with the metabolic diseases(hypertension,diabetes) and liver steatosis; 2. There was no significant difference in the prognosis between SH-HCC and non-SH-HCC patients after curative heaptectomy.