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A Study On The Evaluation Of Hemodynamics In Patients With Heart Failure By Non Invasive Hemodynamics Combined With BNP And Left Ventricular Ejection Fraction

Posted on:2017-05-16Degree:MasterType:Thesis
Country:ChinaCandidate:M H LiFull Text:PDF
GTID:2334330491950994Subject:Internal Medicine
Abstract/Summary:PDF Full Text Request
Heart failure is a complex syndrome caused by various kinds of cardiovascular diseases. It is the final stage of cardiovascular disease, and it has a high incidence rate and mortality rate. Previous studies have shown that patients with clinical symptoms of heart failure and its mortality is similar to malignant tumors, has become a global concern about the health problems of [1], effective and reasonable treatment is to reduce mortality, get a good prognosis of the key [2]. The reason and the key link of each case are different, so the accurate assessment and judgment of the heart failure is very important to the treatment. At present, the widely used evaluation methods include physical and chemical examination such as X-ray, ultrasound, BNP, etc., in particular, ultrasound and BNP are the most common [3], accuracy is widely recognized. However, noninvasive hemodynamic monitoring with high sensitivity to the impedance method is not applied in clinical practice.The significance of this study through the application WA-820 digital impedance blood flow diagram tester determination of 87 cases of patients with heart failure of the noninvasive hemodynamic parameters, and determination of echocardiography and brain natriuretic peptide(BNP) level, and noninvasive hemodynamics and BNP and left ventricular ejection fraction were analyzed by correlation analysis, explore the three indicators in the evaluation of cardiac function and non invasive hemodynamic monitoring in guiding the clinical treatment of practical significance.87 cases of heart failure patients, male 48 cases, female 39 cases, aged from 49 to 91 years old, average(73.21 + 9.14). For August July 2014 to 2015 due to various causes(hypertensive heart disease 24 cases, 38 cases of coronary heart disease(CHD), expansion of cardiomyopathy in 25 cases admitted in our hospital department of Cardiology and ICU and excluded in wall injury, pneumothorax, mechanical ventilation, blood loss shock. All selected patients were in accordance with the Chinese Medical Association cardiovascular disease branch recommended clinical evaluation criteria for heart failure [4-5].After the patient is admitted to hospital within 48 hours after extraction of plasma and sent to the laboratory for and BNP levels were measured by American biosite company produced the BNP kit and triage dry fast quantitative myocardial infarction heart failure diagnostic instrument, detection range for 5-5000pg/ml. Using both Tianjin Wanan Kangtai Medical Technology Co., Ltd. is the production of digital WA-820 impedance blood flow graph detector digital WA-820 impedance blood flow diagram tester expert diagnosis system in accordance with the instructions by medical professionals with 4 pieces of heart function detection electrode, neck two pieces were pasted with left and right chest lock mastoid provided mark; chest two pieces respectively pasted with subxiphoid margin anterior axillary line level position. Detection electrodes have to be in close contact with skin, try not to leave gaps, and the electrode strip or in a test at the skin coated with saline or alcohol, reduce fat, increase the electrical conductivity, detect and record all the 40 item parameters. Cardiac ultrasonography in all patients with heart failure.Divided into three groups according to the left ventricular ejection fraction, LVEF<40% group, 40-50% of the group, with group; 40 parameters statistics in 3 groups of patients with WA-820 digital impedance rheogram detector recorded 14 heart function indexes of Wa, O / C, TPR, pcap, SW, CW, SWI, SV, Co, Ci, hi, C observed with changes in left ventricular ejection fraction has to change.The results of this study are as follows: 1.WA, O/C, TPR, PCAP, SW, CW, SWI, SV, CO, CI, HI, C with the increase of BNP, there is a significant change, the difference was highly statistically significant(P<0.001). BNP and atrial contraction wave amplitude(WA)(R=0.885(P < 0.01), the diastolic function index(O / C)(R=0.881)(P < 0.01), and total peripheral resistance(TPR)(R=0.897)(P < 0.01), and pulmonary artery wedge pressure(pcap)(R=0.846 P < 0.01 were positively correlated; and each Bo acting(SW)(r =-0.730 P, acting CW)(R=-0.731(P < 0.01), Bo work index(SWI)(R=-0.746(P < 0.01), and cardiac output(SV)(R=-0.773 heart amount of COR=-0.783(P < 0.01), and cardiac index(CI)(R=-0.759(P < 0.01), the systolic force index(HI)(R=-0.857(P < 0.01), and ventricular systolic wave amplitude(c)(R=-0.488(P < 0.01) was negatively correlated;2. cardiac left ventricular ejection fraction was different, non invasive hemodynamic monitoring WA, O/C, TPR, PCAP, SW, CW, SWI, SV, CO, CI, HI, C,, there was statistical significance(P<0.05). WA, O/C, TPR, PCAP, LVEF, SW, CW, SWI,, SV,,, CO, CI,, HI, C,, the higher the LVEF.The above research results show that: the BNP from the overall evaluation of the functional status of the heart, left ventricular ejection fraction from the systolic function angle to evaluate cardiac function, these indicators and response heart function indexes without invasive hemodynamic indexes have good correlation, and without a many indexes of hemodynamics can be from heart failure causes and key links of more detailed and specific assessment of cardiac function, provide an important basis for clinical diagnosis and treatment.
Keywords/Search Tags:non invasive hemodynamic, brain natriuretic peptide, left ventricular ejection fraction, heart failure
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