| Objective:Through the clinical study of 30 cases of Yiqi Huoxue Decoction "in the treatment of pulmonary arterial pressure, pulmonary hypertension leads to right heart failure syndrome of qi xu xue yu zheng were observed on the pulmonary artery systolic pressure, blood Pro BNP, right ventricular ejection fraction, cardiac functional grading and six minutes walk test the effects and safety of medication.Methods:According to the inclusion criteria, 60 patients with right heart failure caused by pulmonary hypertension were selected and randomly divided into 2 groups,Western medicine control group and Chinese medicine treatment group(Yi Qi Huoxue Decoction group),Patients usually do not change habits.Western medicine control group of 30 cases,Given the conventional western medicine treatment: Digoxin 0 125 mg Po QD 20 mg Po QD furosemide tablets, Spironolactone Tablets 20 m Po QD 25 mg Po tid., sildenafil.Chinese medicine treatment group of 30 cases, and in the conventional treatment of Western medicine based on the use of traditional Chinese medicine decoction, day one dose, sooner or later.Two groups were given 3 courses(4 after a course of treatment) treatment, observation of patients before and after treatment of pulmonary artery systolic blood pressure, blood Pro-BNP, right ventricular ejection fraction, cardiac function classification, six minutes walk test change, so as to evaluate the efficacy.Result:1.Heart function:Displayed by right heart function between the two groups, control Yiqihuoxue prescription group and Western medicine group after treatment have improved significantly, but Yiqihuoxue prescription group is better than western medicine control group, Yiqi Huoxue Recipe group and Western medicine control group was statistically significant that Yiqihuoxue prescription group increased obviously strong right ventricular ejection fraction;2.In pulmonary hypertension:Echocardiography showed that the two groups of patients in the treatment of pulmonary arterial hypertension have decreased, but the reduction in the group of Qi and activating blood circulation is higher than western medicine control group, the difference between the two groups was statistically significant, but the difference was small.3.Pro-BNP after treatment:The two groups of patients were significantly decreased, and the treatment group was superior to the western medicine group.4.Six minutes walking test results before and after the experiment: two groups of patients have increased walking distance, the Qi and blood circulation group is better than western medicine control group, the results of the two groups have statistical differences.5.Comparison of curative effect of Chinese medicine syndrome,Yiqi Huoxue Recipe group were markedly effective in 12 cases, effective in 16 cases, invalid in 2 cases, aggravated cases, efficiency 93.99%, western medicine control group, markedly effective in 4 cases, 22 cases were effective, 4 cases ineffective, aggravated cases, effective rate was 83.33%, Yiqi Huoxue Recipe group effective rate higher than that of the control group,TCM syndrome score through the rank and test treatment group than the control group, there was statistical significance.6.Comparison of curative effect of heart failure:Yiqi Huoxue Huatan Decoction group markedly effective in 14 cases, effective in 14 cases, invalid in 2 cases, 0 cases aggravated, 93.33%, the control group, 6 cases were markedly effective, 20 cases were effective, 4 cases ineffective, aggravated cases, effective rate is 86.67%, the treatment group with efficiency is better than the control group, heart failure TCM integral by the Wilcoxon rank sum test for treatment group was better than that of the control group.7.In the heart function classification, two groups of patients after treatment were improved, the treatment group improved better than the control group, but the gap is not obvious.Conclusion:Effect of method of yiqihuoxuefang in the treatment of pH induced by right heart failure TCM treatment can significantly improve the symptoms of traditional Chinese medicine, significantly reduce pulmonary arterial hypertension and pro BNP level and improve the six minute walk test value is ignored method in treatment of pH induced by right heart failure. |
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