Synthesis Of Magnetic Nanoparticles And Applications For Tumor Diagnosis And Therapy

Cancer has been a worldwide topic due to the serious effects on human beings. Nowadays, commonly used methods for cancer therapy are surgery, chemotherapy and radiation therapy, have some limitations such as side effects. Magnetic nanoparticles ?MNPs? have attracted tremendous attention for cancer detection and therapy due to the unique physical properties. In this dissertation, we designed two kinds of multifunctional systems based on MNPs. The main contents include:1. We presented a novel type of magnetic-fluorescent bifunctional nanoparticles ?NPs?. Fe₃O₄ nanocrystal and cationic fluorescent star polymer perylene diimide-poly?2-aminoethyl methacrylate? ?PDI-PAEMA? were simultaneously encapsulated into silica matrix by one-pot method. The morphology and fluorescence properties of Fe₃O₄/PDI-PAEMA@SiO₂ core-shell NPs were investigated by ultraviolet-visible ?UV-vis? spectrometry, fluorescence spectrometry and high resolution transmission electron microscope ?HRTEM?. The analysis of in vitro intracellular uptake and cell viability revealed that the bifunctional NPs possessed good biocompatibility. Taken together, the Fe₃O₄/PDI-PAEMA@SiO₂ NP could be a promising candidate for bioimaging due to its stable red emission and good biocompatibility.2. We developed a theragnostic system based on human serum albumin ?HSA? functionalized CoFe2O4@MnFe2O4. CoFe2O4 NPs were synthesized by an improved thermal decomposition method. We take advantage of the exchange coupling between magnetically hard core CoFe2O4 and soft shell MnFe2O4 to improve the conversion of electromagnetic energy into heat. This theragnostic system could be a promising drug delivery platform which combined photothermal therapy and chemotherapy.