The Three-dimensional Reconstruction And Hemodynamic Analysis Of Arterial Vascular

Cardiovascular disease is still the leading cause of death all over the world, the number of people die from cardiovascular disease up to 17.3million, middle-income countries account for 80%, and there is an increasing trend. In China, the number of patients with cardiovascular disease as high as 290 million, of which cardiovascular disease caused by the hypertensive patient 270 million. Patients with hypertension incidence rate of 18.8%, and the prevalence is rising phase. Atherosclerotic plaque is the main reason leading to vascular stenosis and thus lead to cardiovascular disease. Currently, angiography is one of the primary means of diagnosis of vascular disease, use of this technology available to real geometry of blood vessels, hemodynamic distribution in the different shapes blood vessels will affect the formation and development of atherosclerotic plaque. Get real internal dynamics distribution of blood vessels in a cardiac cycle, study of blood flow characteristics in different structures and stenosis vascular, explore atherosclerotic plaque formation and development mechanisms and the causes of vascular disease complications, for early interventional treatment of cardiovascular disease provide a theoretical basis.This paper studies the problem for atherosclerotic plaque formation?vessel model simplification and atherosclerotic plaque location. use the clinical vascular CT data, established the model of coronary artery(LCA, RCA) and carotid artery(CCA) in Mimics16.0, and on the basis of model reconstruction of the left circumflex coronary artery(LCX) established its simplified model in Pro/E5.0, using computational fluid dynamics methods analysis the influence of different structures of vascular on blood flow, explore the influence of vessel model simplification on numerical calculation. In addition,do in vitro blood experiments on the left circumflex coronary artery, and then verify the reasonableness of numerical analysis.In this paper, the main research work and achievements are as follows:1. Establish the blood model by use artery CT data on the three-dimensional reconstruction software Mimics16.0, obtained LCA, RCA, CCA three-dimensional geometric model with vascular disease, provide the theoretical basis for the stent design and interventional treatment of vascular.2. According to the stenosis RCA model establish its normal vascular geometry model in 3-matic 8.0 in, use the finite element software ANSYS-CFX analysis the blood flow situation on stenosis and Non-stenosis right coronary artery, stenosis of blood vessels greater impact on blood flow characteristics, mainly in the flow velocity near the vessel is reduced, the distal end portion of plaque in the low wall shear force with complex blood flow, the blood flow velocity in stenosis downstream reduced, blood flow is reduced, affecting the normal metabolism of the downstream tissues and organs.3. in order to reduce the numerical computational effort, explore the impact of numerical between simplified and three-dimensional blood vessel model, use of equal cross-sectional area simplified the LCX three-dimensional reconstruction model, calculated the simplified and non-simplified LCX model blood flow situation. The result show that, The vessel simplification can greatly reduce the computational workload, vessel simplification have less influence in calculation result, the different result do not affect to explain formation of atherosclerotic plaques and development mechanism.4. Analysis of the blood flow characteristics of left and right carotid artery and its branches, and found that in the narrow part, bending and branching position of artery have more varied flow pattern, and then study the flow characteristics in different branche angle and bend vessels, obtained the position atherosclerotic plaque easy to form, provides a theoretical basis to prevention of vascular diseases and production of stent.5. Use of industrial-grade 3D printer produced LCX solid model according to three-dimensional reconstruction modle, and its blood flow characteristics results in vitro experimental and numerical are basically the same, the blood flow in distal end of plaque is complex, vascular stenosis easily lead to the inlet pressure increases, the pressure downstream of the stenosis is reduced. Verify the reasonableness of numerical calculation in this article.