| Objective:Analysizing the clinical data and TCM four diagnostic information of 81 patients with T2DN(?,? stage)to research on the clinical characteristics and the regularities of TCM syndrome element distribution of T2DN.Aimed to search for the risk factors of the disease and provide the reference for its TCM dialectical treatment.Methods:First Studied the patients who meet the requirements based on the unified questionnaire to collecte the clinical data and TCM four diagnostic information.Then combined with "science syndrome factor differentiation" in "Syndrome Rating Scale" to extract syndrome element.Last used descriptive statistical analysis and other methods to analyze the clinical features,and summarized the regularities of distribution of TCM syndrome elements.Result:1.In this study the prevalence of T2DN in males is higher than in females(1.7:1);the average age of whom is 56.69±8.65 years;the peak age is 51-60 years,accounting for 49.38%;the prevalence of who older than 70 is significantly reduced;the mean disease duration of DM is 10.46±5.62 years;overweight and obese patients are more than others,accounting for 65.43%.2.There is no statistical significance between stage ? patients and stage ? patients in average age and average BMI after compared(P>0.05);the average duration of DM in stage ? is longer than in stage ?(P<0.05).3.In this study about 64.20% of all patients combined hypertension?19.75% patients combined renal hypertension,77.78% patients combined dyslipidemia,17.28% patients combined hyperuricemia,14.81% patients combined cerebral infarction,10.17% patients combined coronary heart disease.After compared the proportion of merger hypertension(90.91%/54.24%),renal hypertension(40.91%/11.86%),dyslipidemia(95.45%/71.19%)and hyperuricemia(40.91%/8.47%)of stage ? is significantly higher than that of stage ?(P<0.05),but there is no statistical significance between the two in the proportion of merger cerebral infarction(27.27%/10.17%)and coronary heart disease(18.18%/ 10.17%)(P>0.05).4.SBP?DBP?TC?TG?Cr?UA and Blood ?2MG of Stage ?patients was higher than that of Stage ?(P<0.5 or P<0.01).But there is no statistical significance between the two in FBG?LDL-C?HDL-C?BUN and HbA1c(P>0.05).5.The disease location syndrome elements of T2DN is mainly to kidney,involving the liver,spleen,heart,etc.And mostly plurality syndrome factors are combined which is mainly to the comorbidity of liver and kidney,spleen and kidney.6.The frequencies of disease sexual syndrome elements >10% are as follows:the order of the phase ? is yin deficiency(96.61%)>qi deficiency(61.02%)>heat(47.46%)>yang deficiency(33.90%)> anemia(23.73%)> wet(22.03%)> blood stasis(15.25%)> qi stagnation(13.56%)>sputum(11.86%);the order of the phase ? is yin deficiency(86.36%)>qi deficiency(81.82%)>Yang deficiency(59.09%)>blood deficiency(36.36%)>heat(27.27%)>water retention(22.73%)>blood stasis(18.18%)?wet(18.18%)>sputum(13.64%).7.The disease sexual syndrome elements was classified according to the actual situation,deficiency combination include Yin deficiency,qi deficiency,qi and Yin deficiency,Yin and Yang both deficiency,qi and blood and Yin both deficiency,qi and Yin and Yang both deficiency,qi and blood and Yin and Yang both deficiency,mostly two or more was deficient.Above two deficiencies in stage ?(accounted for 81.82%)are much more than that in stage ?(accounted for 61.02%).Solid venereal elements are more complex,the frequency of occurrence>5%:stage ? include fire syndrome(20.34%),heat syndrome(11.86%),heat stasis syndrome(5.08%)?stasis syndrome(5.08%);stage ? include water retention syndrome(13.64%)? fire syndrome(9.09%)? stasis syndrome(9.09%)? heat syndrome(9.09%).Conclusion:1.Male,age,overweight,hypertension and obesity may be the risk factors for T2DN.2.The course is closely related to the development of type 2 diabetes,and the average course of stage ? is longer than that of stage ?.3.With the development of the disease,the probability of DN patients combined cardiovascular complications and metabolic disease(such as hypertension,dyslipidemia,hyperlipidemia,hyperuricemia,cerebral infarction,coronary heart disease)is increased.4.The disease location of DN is maninly to kidney,involving the heart,liver lung,spleen,large intestine etc.Which is mostly for the disease with multiple organs,and it is mainly to the comorbidity of liver and kidney,secondly for the comorbidity of spleen and kidney.Pathogenes are mainly to intermingled deficiency and excess,that with deficiency of both qi and yin-based,and accompanied with fiery,blood stasis,dampness,phlegm,water stop,qi stagnation etc.With the development of the disease,the hot like was ease,but the qi deficiency,blood deficiency and Yang deficiency were increased,finally both qi,blood,yin and yang asthenia,and water park,blood stasis,phlegm and other pathogenic products as well as increasing. |
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