Correlation Of Procalcitonin,Interleukin-6 Levels With Coagulation Indexes In Lung Cancer Patients

Background and objectiveLung cancer with its high incidence and mortality is highly valued by clinicians, along with the development of the hospital multidisciplinary and comprehensive care model, invasive examination and treatment pattern played an important role in prolong survival period of patients, but a significant increase in the hospital stays, medical burden and the chance of nosocomial infection added, especially in patients with advanced cancer. Related research confirmed that the blood coagulation dysfunction caused by malignant tumor, which can be used as predisposing factors that increase the risk of tumor metastasis and symptoms worse. To observe the parameters of coagulation indexes in lung cancer patients with clinical stages difference, to analysis whether the Procalcitonin, interleukin-6 have correlation with activated partial thromboplastin time, prothrombin time, fibrinogen, D-dimer and Platelet in patients, to explore the the relationship between inflammatory reaction and coagulation indexes, in order to offer reference for clinical rational use of anticoagulation drugs.MethodA retrospective analysis of 165 lung cancer patients (as lung cancer group) and 50 health examination professionals(as control group) enrolled from October 2014 to December 2015 in the second affiliated hospital of Zhengzhou university. The patients grouped by the clinical stages and pulmonary infection situation, to collect and analysis the clinical materials and laboratory results.Results1. The serum concentrations of fibrinogen and D-dimer were higher than those of control group (P<0.05), the levels of activated partial thromboplastin time and platelet counts in lung cancer group were lower than the control group (P<0.05), There were no significant difference in levels of prothrombin time (P>0.05);2. The levels of activated partial thromboplastin time and platelet counts in ?-? stages were higher than the ?-?stages (P<0.05), the serum concentrations of fibrinogen and D-dimer in the ?-? stages were lower than the ?-?stages (P<0.05), there were no significant difference in levels of prothrombin time during the clinical stages difference (P>0.05);3. The plasma levels of activated partial thromboplastin time in infected group were significantly lower than those of non-infected group and control group (P<0.05), there were no significant difference in non-infected group and control group (P>0.05); The plasma levels of prothrombin time in infected group were significantly higher than those of non-infected group and control group (P<0.05), there were no significant difference in non-infected group and control group (P>0.05); the serum concentrations of fibrinogen and D-dimer in infected group were significantly higher than those of non-infected group and control group (P<0.05), while the levels in non-infected group were higher than those of control group (P<0.05); The platelet counts in infected group is below the non-infected group and control group, there were no significant difference in the non-infected group and control group (P>0.05);4. The serum concentrations of Procalcitonin and interleukin-6 in infected group were higher than the non-infected group and the control group (P<0.05), there were no significant difference between the non-infected group and the control group (P>0.05);5. The plasma levels of Procalcitonin in the infected group were positively correlated to the activated partial thromboplastin time, D-dimer (r=0.349; r=0.812) and negatively correlated to fibrinogen (r=-0.358), while there were no correlation with prothrombin time and platelet counts (P>0.05); The plasma levels of interleukin-6 were positively correlated to activated partial thromboplastin time, D-dimer (r=0.317, r=0.783), while there were no correlation with prothrombin time, platelet counts and fibrinogen (P>0.05);6. The plasma levels of Procalcitonin in the non-infected group were positively correlated to D-dimer (r=0.775) and negatively correlated to fibrinogen(r=-0.400), but no correlation with activated partial thromboplastin time,prothrombin time and platelet counts (P>0.05); The plasma levels of interleukin-6 were positively correlated to D-dimer (r=0.573) and negatively correlated to fibrinogen (r=-0.366), while no correlation with activated partial thromboplastin time, prothrombin time and platelet counts (P>0.05).Conclusions1. The levels of D-dimer and fibrinogen were increased by the clinical stages in lung cancer patients, the coagulation state abnormal which might enhance their thrombosis potential;2. The combined detection of serum Procalcitonin and interleukin-6 can be used as indicators for lung cancer patients with pulmonary infection;3. The levels of Procalcitonin and interleukin-6 were strong positively correlated to D-dimer, while negatively correlated to fibrinogen, inflammatory indicators were associated with coagulability indexes, with inflammatory response increased, the coagulation derangement were remarkable;4. We should monitor the inflammatory indicators and coagulability indexes especially on advanced lung cancer patients, in order to control the infection effectively and correct coagulation indexes in early-stage, which can improve the prognosis of patients.