The Value Of Magnetic Resonance Imaging In Marchiafava-Bignami Disease

Objective:To initially study the application value of magnetic resonance imaging(MRI)in findings of Marchiafava-Bignami Disease(MBD).To evaluate the utility of 3D-FLAIR,diffusion tensor imaging and fiber tract-tractography in examination of Marchiafava-Bignami disease.Materials and Methods:During July 2011 and February 2014,Through the hospital 35 cases clinically diagnosed MBD patients MRI imaging analysis,combined with clinical disease occurrence,development and outcome characteristics were compared summary.Review of 18 patients,comparison 3D-FLAIR sequence with conventional FLAIR sequence image display cases for statistical analysis.Summarized 15 cases of patients with MBD 9 normal control group DTI image data,enter the EWS processing platform;ministries of the corpus callosum(mouth,knees,body,press section)and bilateral centrum ovale FA and ADC values were measured value analysis,comparison of FA and ADC values change through statistics.ROI using the manual method outlined in midsagittal corpus callosum range,showing the white matter fiber tracts and generate color-coded FA maps;pair of white matter fiber tracts and changes in color-coded map of FA between MBD and normal on the groups compared.Results:14 cases of patients as acute onset,12 cases as subacute onset,9 cases as chronic onset.8 cases corpus callosum swelling,3 cases normal morphology and 3 patients with mild atrophy of 14 cases of patients as acute onset.9 patients with normal morphology of the corpus callosum,2 cases mild swelling and 1 case atrophy of 12 cases as subacute onset.6 patients corpus callosum atrophy and 3 normomorph of 9 cases as chronic onset.35 cases all the lesions of corpus callosum were symmetrical.33 cases lesions of corpus callosum are whole and 2 cases are partial.34 cases of the edge of corpus callosum are clear and 1 case is not clear.24cases with " sandwich biscuit "signs,19 cases with the corpus callosum middle cystic necrosis.the lesions outside the corpus callosum are found in 34 case of all patients,which are roughly symmetrical.The lesions of centrum semiovale are the most common and the lesions of temporal and occipital white matter or cortex are the most rare.more than 1/3 of cases the lesions of the anterior commissure or cerebellopontine angle are found.By conventional FLAIR,we find 4 cases of anterior commissure abnormal in 18 patients,but by 3D-FLAIR we find 10 cases of anterior commissure abnormal of them.We find 3 cases of cerebellopontine angle abnormal in 18 patients by both conventional FLAIR and 3D-FLAIR.For larger lesions(>5 mm),the scope of lesions on 3 D-FLAIR and conventional FLAIR show no significant difference,but the boundary of the lesion on 3D-FLAIR is clearer than the lesion on routine FLAIR.In July 2011-February 2014 of 17 MBD,15 cases of successful follow-up,one patient died;14 cases of clinical symptoms improved or disappeared,improved quality of life to varying degrees.The FA values of the measurement points are statistical difference and the ADC values of the measurement points are no statistical difference between 15 cases of MBD group and 9 control group(P<0.05).The amount of the fiber of corpus callosum of chronic onset group is less than the same age control group,the color satu-ration of the color coded FA Figure of chronic onset group is lower than the control group;the amount of the fiber of corpus callosum ofsubacute and acute onset group is the roughly same ascontrol group,there is no difference between the color saturation of the color coded FA Figure of subacute and acute onset group and the control group.Conclusion:MRI can clearly show the corpus callosum lesion morphology,size and signal characteristics;especially 3D-FLAIR sequence on display outside their corpus callosum lesions and small lesions has obvious advantages.By DTI imaging technology,combined with changes in FA values and ADC values,an accurate diagnosis of the corpus callosum and white matter lesions in myelin,is reasonable and feasible.FA FIG change color coding information as a visual image,the patient to better show MBD corpus callosum fiber bundle.Master these features,on the occurrence or identification of lesions involving the corpus callosum will be of great help.Follow-up of patients in this group are short-term prognosis of follow-up,the prognosis long-term follow further study.