| My tutor Yang Nizhi is a PhD supervisor, postdoctoral associate professor of Guangzhou University of Chinese medicine Professor of medicine, chief physician, and the fifth installment of the old doctor of traditional Chinese medicine academic experience inheritance tutor, the nephropathy headman of Guangdong province Hospital of traditional Chinese Medicine. She engaged in the Department of internal medicine, teaching and scientific research work for thirty years. ProfessorYang had clinical experience on the Department of internal medicine disease, especially in the diagnosis and treatment of the kidney. disease. Yang teacher put forward yiqi huoxue method for the treatment of chronic kidney disease of academic ideas, become the representative figure of lingnan nephrosis internal medicine of traditional Chinese medicine. This study is divided into three parts:1. The academic thought origin of tutor Professor Yang NizhiThe academic thought origin comes from the Internal Canon of Medicine, Classic of Questioning, Corrections on the Errors of Medical Works. She was influenced by the modern expert such as Zou Yunxiang, Zhang Qi, Zhang Daning, etc. She inherits the theory of classics and the thought of experts. Combined with the main syndrome of chronic kidney disease, Qi deficiency and blood stasis syndrome is always exists in chronic kidney disease. In long-term clinical practice, she puts forward the theroy of Qi and blood are always exist in the disease, she also thinks Qi deficiency and blood stasis is the reason of kidney disease, which reflects the tutor respect for the acient theory but is not limited by the acient theory, and has the innovative academic style.2. Professor Yang Nizhi's academic thoughts and clinical experienceProfessorYang had rich experience, she emphasizes the combination of dialectical and differentiation. Advocate the combination of TCM and Western medicine, disease and syndrome differentiation. Treated by supplementing qi and activating blood circulation method on prevention and treatment of chronic kidney disease, the method of Yiqi Huoxue Qingre on chronic glomerularnephritis, Yiqi Huoxue Lishui, the treatment of refractory nephrotic syndrome, supplementing qi and activating blood circulation of TCM Comprehensive Measures delaying chronic renal failure, traditional Chinese medicine combined with hemodialysis and peritoneal dialysis in the treatment of end stage renal disease and other methods has obvious curative effect.3. The clinical experience of Professor Yang Nizhi in treating chronic kidney disease----Analysis of the characteristics of the treatment of chronic nephritis by Professor Yang Nizhi based on data mining methodData mining is a process that is effective, novel, potential application value and the ultimate understandable pattern in nature. It aims to help explain the current behavior or predict future results. It is a research hotspot in the current international scientific and technological circles. It has a wide range of applications in the fields of statistics, pattern recognition, artificial intelligence, machine learning, database technology and high performance parallel computing.ObjectiveThe purpose of this study was to explore the theoretical understanding of the etiology and pathogenesis of chronic kidney disease, and to sum up the clinical experience of treating chronic kidney disease, and by raining the treatment characteristics of medication and rules of treating chronic nephritis. To sum up the academic thoughts and experience of treating chronic kidney disease by using the method of Supplementing Qi and activating blood circulation, to find the breakthrough point for the treatment of chronic kidney disease, and to determine the advantages of the treatment of chronic kidney disease, to prevent the occurrence of complications such as infection, low protein and so on. By analyze Professor Yang Nizhi's chronic nephritis medical records data mining and medication, prescription rules and characteristics of the formula. At the same time, the application of modern new technology to the traditional Chinese medicine in the treatment of CKD, the scientific interpretation of the treatment method.MethodsThe investigation of past medical records, summary of the experience of chronic nephritis experience.Investigate the past medical records, summary the experience of chronic nephritis experience. Medical record information source:96 patients who are in accordance with the diagnostic criteria for chronic nephritis, and was diagnosed of CKD in YangNizhi, s Department or internal medicine of Guangdong Province Traditional Chinese Medical Hospital.Diagnostic criteria:The diagnostic criteria of CKD are defined by the current internationally recognized NKF a K/DOQI working group. Diagnostic criteria for chronic nephritis:referring to Wang Haiyan, the chief editor, "kidney disease," the third edition. The traditional Chinese Medicine Research Institute of traditional Chinese medicine heritage auxiliary platform software V2.5, Using data mining method based on frequency statistics, association, clustering and network analysis, For the treatment of syndrome differentiation and treatment, the choice of medicine, The frequency of the use of various drugs and the association rules between drugs. Unified entry of treatment of 96 cases of 288 cases of chronic nephritis cases, data cleaning, mining analysis, the frequency use of various drugs and the association rules between drugs, analysis the characteristics of drug use in the treatment of chronic nephritis.ResultsThe results of 96 patients TCM differentiation types indicated that the cause of chronic nephritis mainly lies in five aspects of deficiency in origin and enrichment in symptom, which contain five syndrome:Qi deficiency and blood stasis of spleen and kidney;Qi and yin deficiency, damp heat and blood stasi; Qi and yin deficiency, damp heat and blood stasis;Spleen and kidney qi deficiency, water resistance Shiyu; Spleen kidney qi deficiency, dampness and blood stasis obstruction. Make a Summary of the medication, higher frequency use of the top 20 Chinese medicine respectively:Herba Lycopi, glossy privet fruit, Radix Astragali, radix salviae miltiorrhizae, Radix Paeoniae Alba, Radix Polygoni Multiflori, Rhizoma Atractylodis Macrocephalae, prepared rehmannia root, Codonopsis pilosula. The patients included in study mainly concluede fatigue, lumbago, appetite poor as the main symptoms, and associated with foam in urine, limb swelling and other chronic kidney disease other symptoms. Most of the tongue and pulse number is yellow and greasy fur, big fat tongue, the tongue body is normal, the tongue color dark red, deep and fine pulse, thready pulse. In the treatment of chronic nephritis of different syndrome types using different methods of treatment, spleen and kidney qi deficiency and blood stasis type with commonly used drugs, fill bad drug commonly used Astragalus, white atractylodes rhizome, Radix Pseudostellariae, glossy privet fruit, Eclipta, eucommia bark, radix salviae miltiorrhizae, semen persicae, Zeeland. Spleen and kidney deficiency and damp heat and blood stasis syndrome commonly used drugs:Radix Pseudostellariae, largehead atractylodes rhizome, dandelion, Rhizoma Smilacis Glabrae, Salvia miltiorrhiza, Zeeland, Rhizoma alismatis. Deficiency of both qi and Yin, damp heat and blood stasis syndrome in medical records commonly used drugs are: ginseng, Atractylodes, glossy privet fruit, Eclipta alba, Rhizoma Smilacis Glabrae, dandelion, radix salviae miltiorrhizae, Eupatorium. By make statistics and data mining of 288 prescriptions, summed up the 5 pairs which is associated with a higher degree of drugs:Astragalus Atractylodes, Astragalus adenophorum, Astragalus and Salvia miltiorrhiza, Eupatorium salvia, Salvia miltiorrhiza, peach kernel. And draw 3 new prescriptions for the treatment of chronic kidney disease:Ligustrum Eclipta mountain cornelian cherry meat Danshen Huangqin and Baizhu, Salvia miltiorrhiza Lycopus lucidus Codonopsis pilosula Radix Rehmanniae Preparata coix seed Rhizoma imperatae, Houttuynia cordata soil Poria Astragalus Radix Rehmanniae Preparata coix seed Rhizoma imperatae.ConelusionProfessor Yang Nizhi think the pathogenesis of chronic nephritis is the virtual reality, deficiency of spleen and kidney is the basis of the disease, water dampness and blood stasis are as the subject. She think the chronic nephritis mainly has relationship with spleen and kidney. Therefore, in the treatment of chronic nephritisthe,Professor Yang pay emphasis on "kidney and spleen, strengthen Qi and remove blood stasis". In treatment of drug use, it is not only to adhere the principle of differentiation and treatment, but also combined with the modern pharmacological research methods for the treatment of the system. In treatment of chronic nephritis prescription generally emphasize Qi,and pay equal attention to promote blood circulation and removing blood stasis, such as the use of reinforcing Qi medicine:SRadix Codonopsis, Radix Astragali, Radix Pseudostellariae, largehead atractylodes rhizome etc. And the promoting blood circulation drugs:Salvia miltiorrhiza, Zeeland, peach kernel, safflower; Fructus Corni, tangerine peel, tuckahoe, Radix Pseudostellariae, Pyrrosia lingua.I have applied mining techniques to study eminent TCM doctors' experiences, and the outcome is in line with clinical practices.It has great importance for the summary of eminent TCM doctors' experiences. |
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