The Clinical Observation Of Oxycodone For Brachial Plexus Nerve Block

Objective: The main aim of the present study was to examine the clinical efficacy of composite use of the oxycodone hydrochloride with lidocaine hydrochloride and ropivacaine hydrochloride for interscalene brachial plexus block anesthesia method.Methods: 40 patients scheduled for upper limb surgery were recruited from our hospital,and patients was classified into stage I or II based on criterion of the American Society of Anesthesiology(ASA),then were randomly divided into control(n=20)and treatment group(n=20).For the control group,a combination of lidocaine and the ropivacaine was used with respective dose of 1% and 0.25%(25 ml);for the treatment group,a combination of the lidocaine,the ropivacaine and oxycodone was used with respective dose of 1%,0.25% and 5 mg(25 ml).Anesthesia process: The method of brachial plexus block was adopted for all patients,the patients took back with head turning to the opposite side,the shoulders were down,and the limbs were attached to the body.The anesthetist faced the patient.Once the patient felt uncomfortable,he/she must immediately inform the anesthetist without moving head.Touch low edge of the thyroid cartilage(equivalently to the transverse of the sixth cervical vertebra),and feel the sternocleidomastoid trailing edge,then slightly move outside,the gap touched is the former and middle scalene muscle ditch,then down to omohyoid muscle on the edge,that is the puncture point.After finding the puncture point,for the control group,a combination of lidocaine hydrochloride and the ropivacaine hydrochloride was used with respective dose of 1% and 0.25%(25 ml);for the treatment group,a combination of the lidocaine hydrochloride,the ropivacaine hydrochloride and oxycodone hydrochloride was used with respective dose of 1%,0.25% and 5 mg(25 ml).After drug injection,the oxygen hydrochloride was given to the patient with venture mask(3L·min-1).Outcomes: The outcomes of the present study including(1)patient's vital sign 30 min after anesthesia like respiratory rate(RR),blood pressure(BP),pulse rate(P),blood-oxygen saturation(Sp O);(2)onset time of anesthesia calculated by the difference between the time of anesthesia injection and the starting time of surgery;(3)duration of anesthesia calculated by the difference between onset time of anesthesia and the time of pain to the patient;(4)the evaluation of Anesthesia effect and satisfaction rate of anesthesia;(5)adverse reactions like nausea and vomiting,respiratory depression,dizziness,skin itching,urinary retention.Results: Between the two groups,there were no significant difference of height,weight,age and proportion of gender(P > 0.05),also respiratory rate,blood pressure,pulse rate and blood-oxygen saturation were not statistically different between the two groups(P > 0.05).Compared to the control group,the treatment group had significantly shorter onset time of anesthesia(P < 0.05),longer duration of anesthesia(P < 0.05)and higher satisfaction rate(P < 0.05).Conclusion: Our study showed that the joint use of the oxycodone hydrochloride and the local anesthetics by brachial plexus block anesthesia method can significantly reduce the onset time of anesthesia and increase duration of anesthesia,while it have higher satisfaction rate and preventing adverse reactions events such as nausea,vomiting,respiratory depression.It is recommended for the further clinical application.