| Objective Established mouse model AR, AR mouse serum Ig E comparison, IL-4, IFN-? changes, explore the pathogenesis of AR; serological changes by comparing the treated mice to explore the therapeutic agent through nasal magnolia AR mechanism. High energy focused ultrasound clinical data of patients in the control group were analyzed to explore the advantages and disadvantages of focused ultrasound therapy for AR; investigate the therapeutic effect of focused ultrasound combined with magnolia mixture through the nose, and long-term efficacy of the treatment group, understand magnolia mixture on change through the nose It should rhinitis chest distress, coughing, itchy throat and other symptoms of nasal external intervention.Methods Using mice were randomly divided into control group, model group, the treatment group of three groups of eight mice. Model group and treatment group modeling allergic rhinitis, after modeling successfully administered through nasal treatment group magnolia mixture 10 ml / kg orally, three groups of mice two weeks after collection of serum for analysis.Patients with allergic rhinitis, Wuhan First Hospital from October 2013 to September 2015 in the Department of Otolaryngology, 112 hospitalized patients were studied. The patients were randomly divided into two groups, a control group of 56 patients in this group of patients taking only focused ultrasound surgery for the treatment; the treatment group of 56 patients in this group of patients in addition to taking focused ultrasound surgery methods, beginning after the second day taking magnolia nose through agents, treatment for 14 days, day one, day three, all patients the day after surgery two weeks after surgery 12 weeks, 24 weeks after surgery recorded symptom scores before surgery to obtain a markedly effective invalid number of cases, to observe and record changes over time. Saccharin patients willing to participate in the experiment in two weeks after the experiment was conducted, and the results obtained record observations. Two groups of patients were recorded before surgery day, 14 days suffocation chest tightness, redness, eye itching, tearing, the number of cases of cough, observe and record changes in the number of patients after surgery.result1. animal experiments, serum Ig E model group, the content of IL-4 compared with the control group was significantly increased, while the level of IFN-? compared with the control group was significantly lower, the difference was statistically significant; magnolia mixture through nasal treatment group compared with model group serology mice, Ig E, IL-4 content decreased, the content of IFN-? increases, the difference was statistically significant; explain the pathogenesis of AR and Ig E, IL-4, IFN-? levels of correlation,magnolia nose through their agents play a therapeutic role to regulate Ig E, IL-4, IFN-? levels is related to one of the mechanisms of AR treatment.2. Select the control group, the treatment group patients gender, average age, the two groups before treatment scores were not statistically significant. Before treatment score 10.29 ± 3.12, 11.05 ± 2.74. Nasal mucociliary clearance time before and after treatment compared with the control group before treatment 617 ± 91, 609 ± 134 after treatment; respectively before and after treatment, 599 ± 78, 438 ± 116. After two weeks of treatment, both groups after 12 weeks of treatment for the overall result of the comparison are: P> 0.05, the difference was not statistically significant. After 24 weeks of treatment, and then compare the two groups overall: p <0.05, the difference was statistically significant.3. The control group before and after treatment and disease in addition to itchy eyes(p <0.05) have some differences, the other had no clear therapeutic effect. The treatment group before and after treatment and disease was statistically significant(p <0.05), indicating the treatment group magnolia Bitongshui mixture on the treatment of disease and play a major role, and the treatment difference between the two groups and disease was statistically significant(p < 0.05). The treatment group magnolia mixture on the treatment of nasal disease and in descending order of cough> itching> chest suffocation> cry> jealous, it can be speculated magnolia Bitongshui agent for cough, itchy eyes, chest distress and disease these treatment effect is more prominent in patients with AR.Conclusion Animal experiments confirmed that the currently accepted one AR pathogenesis Th1 / Th2 cytokine imbalance theory, also obtained through the nose magnolia mixture in the treatment of allergic rhinitis and its functioning mechanism can be adjusted out of balance Th1 / Th2 cells factor, i.e. reduced Ig E, IL-4 levels, increased levels of IFN- ?, to achieve therapeutic effect. Higher safety performance focused ultrasound, focused ultrasound combined with magnolia mixture through the nose for the treatment of allergic rhinitis than simply focused ultrasound treatment effect is good, and the long-term efficacy for AR is more satisfied. Magnolia nose through agent not only can relieve nasal symptoms of allergic rhinitis and signs for the performance of the external nasal symptoms such as coughing, itchy eyes, chest tightness, also have a more significant positive effect, suggesting that this may affect the long-term treatment group a positive factor efficacy in clinical use should be selected. |
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