To Explore The Change And Significance Of Estradiol In The Female Patients With Papillary Thyroid Carcinoma

Objective: To observe the female patients with Papillary thyroid carcinoma estradiol(E2)changes and explore its significance.And to analyze correlation between the estradiol in the blood of Papillary thyroid carcinoma cases which have a complication of Hashimoto's thyroiditis and the thyroglobulin antibody(TGAb).Methods: By the conventional ultrasound,collect respectively 35 women with Papillary thyroid carcinoma(Papillary thyroid carcinoma group)pathologily confirmed in reproductive and postmenopause,33 women with benign lesions(benign lesion group)and 30 volunteers(control group),and compare the changes of estradiol in the blood in reproductive and postmenopause,and analyze the significance of estradoil in papillary thyroid carcinoma.To compare the statistical meaning of thyroid nodule in each ultrasonography parameter(such as hypoechoic,aspect ratio ? 1,ragged edges,microcalcification),which between the papillary thyroid carcinoma group and the benign lesion group in reproductive and postmenopause,and to explore the significance of each ultrasonography parameter;to compare the statistical meaning of difference in incidence of illness between papillary thyroid carcinoma cases,which have a complication of Hashimoto's thyroiditis and patients with benign lesions,which have a complication of Hashimoto's thyroiditis in all collection objects.At the same time,to analyze the correlation between estradiol in the blood of the papillary thyroid carcinoma cases which have a complication of Hashimoto's thyroiditis and the TGAb.Results: In reproductive and postmenopause,The estradiol level of Papillary thyroid carcinoma group are 99.65 ±14.98 ng/L,32.03 ± 13.94 ng/L,The estradiol level of benign lesion group are 92.19 ± 9.88 ng/L,25.26 ± 11.12 ng/L,The estradiol of control group are 88.86 ±12.06 ng/L,21.88 ± 9.57 ng/L.Compared to benign lesion group and control group,estradiol level of Papillary thyroid carcinoma group is significantly higher(P< 0.05).However,compare with the control group in reproductive and postmenopause,the estradiol level of the benign lesion group is higher,but it is no statistical meanings(P >0.05).In conventional ultrasonic inspections of thyroid gland,both papillary thyroid carcinoma group and the benign lesion group in reproductive,each parameter of ultrasonography for respectively is hypoechoic(30/35?20/33),aspect ratio?1(28/35?5/33),ragged edges(33/35?9/33),and microcalcification(18/35?3/33);while in postmenopause,each parameter for respectively is hypoechoic(31/35?23/33),aspect ratio?1(30/35?2/33),ragged edges(29/35?3/33),microcalcification(15/35?2/33).Compare each parameter of ultrasonography between the papillary carcinoma group and the benign lesion group in reproductive and postmenopause,it has statistical meanings(P<0.05).While compare the proportion of papillary thyroid carcinoma group and the benign lesion group which has a complication of Hashimoto's thyroiditis,it has statistical meanings(P<0.05).Moreover,correlation analysis of the estradiol of papillary thyroid carcinoma which has a complication of Hashimoto's thyroiditis and the TGAb is : r=0.503,P=0.001(P<0.05).Conclusion:The estradiol levels in female patients with Papillary thyroid carcinoma in reproductive and postmenopause were higher compared to the benign and control group,suggested that estradiol may play a important role in pathogenesis in fema le patients with Papillary thyroid carcinoma.While in reproductive and postmenopause the conventional ultrasonic inspections of thyroid gland,thyroid nodule is mostly hypoechoic,aspect ratio ?1,ragged edges,with or without microcalcification.These ultrasonography's parameter has much higher sensitivity and specificity to the diagnosis of papillary thyroid carcinoma,providing some valuable information which has a guiding significance for benign or malignant of thyroid diseases.In all cases,the patients with papillary thyroid carcinoma which has a complication of Hashimoto's thyroiditis are more than those in benign lesion group.Correlation analysis of estradiol level and Thyroglobulin antibody with Papillary thyroid carcinoma patients which has a complication of Hashimoto's thyroiditis,that Papillary thyroid carcinoma and Hashimoto's thyroiditis has remarkable Positive correlation.