Discussion Of Solitary Fibrous Tumor That Related With Obstetrics And Gynecology

Objective: Solitary fibrous tumor(SFT)is a rare spindle cell tumor which originated from mesenchymal tissue.SFT can arise from almost any anatomic sites of the body,however very few cases are found associated with obstetrics and gynecology.In this paper,we summarized 38 cases through the literature retrieval and medical record data from our hospital,analyzed the characteristics of SFT's clinical,pathological,auxiliary examination,therapy and prognosis,in order to accumulate experience for future diagnosis and treatments of SFT in obstetrics and gynecology.Method: Statistically analyzed 38 cases through the literature retrieval and medical record data from our hospital,studied the characteristics of SFT's clinical,pathological,auxiliary examination,therapy and prognosis,utilizing SPSS13.0.Fisher's exact test was applied for the comparison of proportions,P<0.05 was considered statistically significant.The follow-up visit was accomplished by telephone.Results: SFT that related with obstetrics and gynecology has no more than 5 new cases worldwide each year.While the onset age ranges from 20 to 80,most SFT cases occur between the age of 30 and 40.Cases of SFT that involves pelvic cavity,the whole uterus and the surrounding ligament,vaginal and vulvar area are more often seen than SFT that involves the attachment area(ovaries and fallopian tubes).62% of patients experience symptomsin which 45% with local pain,35% with compression symptoms,25% with vaginal bleeding or hypermenorrhea,10% with hypoglycemia.The preoperative misdiagnosis rate is closed to 100%,the most easily misdiagnosed disease is leiomyoma.Making a definite diagnosis relies on paraffin pathology and immunohistochemistry.Immunohistochemistry often presents positive expression of Vimentin,Bcl-2,CD34 and CD99,but negative expression of EMA,Desmin,CK,S-100,CD117,SMA,ER,AE1/AE3,Actin,CD10,CD68 and CD31,etc.Surgery is the main treatment of SFT.The postoperative recurrence rate is 11%.The distant metastasis rate is 8%.All the follow-up records were among 3 months to 11 years with no dead case.Conclusion: The initial symptoms of SFT/MSFT that related with obstetrics and gynecology are local pain,oppression symptoms produced by the tumor,abnormal vaginal bleeding or menstrual changes,hypoglycemia,and weight loss during terminal malignant tumors.Enhanced CT and MRI play roles in preoperative judgement on SFT/MSFT,also provide guiding significance to the understanding of disease preoperative surgery.Relying on surgery to clean out the tumor is the standard treatment of SFT/MSFT at present,with an option of not removing the lymph nodes in the simple SFT/MSFT of obstetrics and gynecology.