| Objective: In patients with pulmonary HRCT scanning glass nodules found in pure and mixed grinding of relevant data statistics and the imaging features of the results with the patient’s postoperative pathological analysis of the correlation,imaging characteristics and pathologic correlation.Methods: Collection stop to March 2016 of the first hospital affiliated to Da lian were analyzed after 324 patients were confirmed by operation and pathology,to 3 cm below the peripheral lung adenocarcinoma and under CT images are characterized by containing pure and mixed grinding glass cases data of the nodule.Collect,determination of 375 cases of ground glass nodules imaging characteristics and the related data;Postoperative pathologic new classification according to the 2011 lung adenocarcinoma pathology infiltration degree is divided into a premalignant lesion group,micro infiltrating adenocarcinoma,infiltrating adenocarcinoma group,all adopt SPSS22 statistical software for statistical data analysis,when the P values < 0.05 was considered statistically significant.Adoption of chi-square analysis in patients with pulmonary nodules between imaging features and pathological types of glass.Recorded cases of ROC curve drawing,to determine the best cut-off point to distinguish between different pathological(Optimal cut-off point).Results: In324 patients aged 61,(61±9.7 mm),minimum age 25,the maximum age85 years old.113patients(34.9%)of men,women,211 cases(65.1%).Pure and mixed grinding glass nodule distribution in the upper148 cases of lung,right lung middle of 21 cases,52cases of right lung lobe,left upper lobe 113 cases,41cases left lower lobe.Between AAH/AIS,MIA and IAC,gender(p = 0.000),age(p = 0.000),levy air-filled bronchi(p = 0.000),leaf(p value is 0.000),burr(p 0.000),shape(p = 0.030),postoperative pathological measure the largest diameter(p = 0.000),volume(p = 0.000),pleural involvement(p = 0.000),tumor markers CEA(p = 0.005)、the SCCA(p = 0.016),imaging measurement from the statistical differences between the various data,and with CYFRA21-1(p = 0.281),NSE(p = 0.194),travel through blood vessels(p value is 0.805),blood vessels,cluster(p 0.424),pleural involvement(p = 0.398),cavity there is no statistical difference(p value is 0.078).In precancerous lesions(AAH/AIS)and micro infiltrating adenocarcinoma(MIA)when pulmonary window sagittal solid component covers long of 0.035 cm,difference between precancerous lesions and micro infiltrating adenocarcinoma,the sensitivity and specificity of the best sensitivity and specificity of 66.1%,91.4% respectively.In micro infiltrating adenocarcinoma(MIA)and infiltrating adenocarcinoma(IAC)when pulmonary window cross-sectional solid ingredients maximum diameter of 0.694 cm,the difference between micro infiltrating adenocarcinoma and infiltrating adenocarcinoma best sensitivity and specificity,sensitivity and specificity of 80.2%,82.4%.Precancerous lesions in the central African typical adenomatous hyperplasia(AAH)and carcinoma in situ(AIS),there was no significant difference between P values > 0.05.Infiltrating adenocarcinoma type sidewall subtypes and acini in subtypes,there was no significant difference between P values > 0.05,gland bubble type subtypes and nipples subtypes,there was no significant difference between P values > 0.05.Conclusion: Lung pure and mixed grinding glass nodules(3 cm or less)and sex,,air-filled bronchi),shapes,leaf,burr,and postoperative pathological measurement of maximum diameter,volume,statistical differences pleural involvement,at the same time by different imaging measurement method can effectively distinguish AAH/AIS,MIA and IAC.But by different imaging measurement method is unable to differentiate effective between precancerous lesions and infiltrating adenocarcinoma of various subtypes. |
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