The Analysis Of Oral Glucose Stimulates Cholecystokinin Pattern In Patients With Type 2 Diabetes

Object: Based on insulin resistance and type 2 diabetes mellitus(or)insulin secretion defects,with or without glucagon increase metabolic disorder.Cause the release of intestinal factor feeding behavior,intestinal factor activated islet beta cell excitability of glucose reaction or by causing intestinal pancreatic shaft amplification glucose insulin release.Element of gallbladder contraction,cholecystokinin(CCK)is a kind of ghrelin that has a variety of molecules,it has to stop feeding,inhibition of gastric emptying,stimulate pancreatic enzyme secretion,promote the gallbladder contraction function.CCK respectively effects on pancreatic acinar cells,gall bladder smooth muscle and control feeding and gastric emptying of the vagus nerve.CCK on feeding behavior,pancreatic cells,regulation of insulin secretion may affect the metabolism of sugar,thereby affecting the onset of diabetes in several ways.Study CCK may play an important role in intestinal promote insulin effect may open new ways of drug therapy for type 2 diabetes.This experimental study in patients with type 2 diabetes and normal subjects in different time after oral glucose serum CCK secretion regularity,understand the impact of oral glucose on CCK secretion.At the same time monitoring of patients with type 2 diabetes and normal subjects in different time after oral glucose in the blood insulin,C peptide,ghrelin(ghrelin)concentrations,analysis the relationship between CCK.Methods:Subjects for March 2014 to November 2014,hebei province people's hospital endocrinology outpatient and ward of the 82 patients included in the study.52 male,female 30,were han Chinese,diabetes diagnosis with reference to the 1999 WHO in the diagnostic criteria of diabetes: Fasting plasma glucose(FPG)or greater tendency for 7.0 / L,or OGTT 2 h blood glucose or greater tendency for 11.1 / L.Control group: no family history of diabetes mellitus 14 cases of healthy control subjects.Respectively,on an empty stomach take sugar after 30 minutes,60 minutes,120 minutes,180 minutes in pursuance.Determination of blood glucose,insulin,C peptide,CCK and ghrelin levels,and statistical analysis.Results: The experimental group of 82 cases,male 52 cases,30 were female,50.42±14.03 years of age,course of 0 to 15 years,6.22±4.91 years,body mass index of 20.48-32.32,an average of 25.55±2.47.Control group in 14 cases,9 cases of male and female in 5 cases,aged 19 to 79 years old,45.71±19.83 years old.Body mass index of 20.05-20.05,with an average of 24.26 ± 2.41.Fasting blood glucose,the experimental group patients take sugar 30 minutes,60 minutes,120 minutes after blood sugar levels are higher than the control group,with statistical differences.Experimental group patients after sugar fasting insulin,insulin levels for 30 minutes,60 minutes,120 minutes were lower than the control group,with statistical differences.Experimental group patients of 60 minutes,120 minutes after sugar CCK level are lower than the control group,with statistical differences.Experimental group patients of sugar after 30 minutes,60 minutes,120 minutes C peptide were lower than the control group,with statistical differences.Experimental group patients take sugar,30 minutes,60 minutes,120 minutes after the ghrelin are lower than the control group,with statistical differences.Conclusion:1 Oral glucose stimulation CCK secretion in patients with type 2 diabetes than normal population decrease,and peak secretion obviously delayed.2 Abnormal ghrelinsecretion may and in patients with type 2 diabetes in empty stomachand aftertake sugarthan normal population decrease.