| Objective: Pramipexole have been used for the treatment of Parkinson’s disease(PD)and Restless Leg Syndrome(RLS).Most studies have shown that the occurrence of impulsive behavior was related to pramipexole.Impulsivity refers to the individual acts without thinking,and low sensitivity to negative behavioral outcomes.They always make a fast and unplanned response before information processing completely,do not consider the behavior consequences.Impulse control is the control of impulsivity.High impulsivity can lead to abnormal impulse control and cause impulsive behavior.Impulse control disorder(ICD)is a psychological disorder which refers to taking certain inappropriate behaviors driven by strong desire.Impulsivity can be divided into behavioral impulsivity and cognitive impulsivity.Behavioral impulsivity is mainly related to impulse control and behavioral inhibition,which performance is lacking of response inhibition.Cognitive impulsivity performance is insensitive to the delayed rewards,and is more inclined to choose to get instant results with long-term damage,while ignoring the long-term benefit accompanied with immediate punishment.This research investigated the impulsiveness characteristics in the patients taking pramipexole.Go/No go laboratory tasks and the Iowa Gambling Task were employed to measure behavioral impulsivity and cognitive impulsivity,respectively.Method: The study included 15 patients in the experimental group and 20 healthy volunteers in the control group.The two groups matched with age,gender,education,MMSE(mini-mental state examination).All subjects were required to complete the Iowa Gambling Task and the Go/No go laboratory task,meanwhile their behavioral performance was recorded.Behavioral data was analyzed by repeated measures analysis of variance.The relationship between the error rate in Go/No go and the performance on the Iowa gambling task,which measured in the experimental group after taking pramipexole,was analyzed by Pearson correlation.Result:1.Iowa Gambling Task: The result showed there was no significant main effect of time(F(1,33)=0.008,p=0.930)in net scores of two groups,and no significant time×group interaction effect(F(1,33)=1.772,p=0.192).2.Go/No go:There was no significant main effect of time(F(1,33)=1.280,p=0.266)in response time,and no significant group×time interaction effect(F(1,33)=0.147,p=0.704).The main effect of time was not significant in error rate(F(1,33)=0.161,p=0.691),and no significant group×time interaction effect(F(1,33)=3.459,p=0.072).There was no significant main effect of time(F(1,33)=0.984,p=0.328)in omission rate,and interaction effect of time×group was marginal significant(F(1,33)=4.487,p=0.042).Post-hoc analysis showed that there was no significant main effect of time in experiment group(F(1,33)=4.232,p=0.048),or in the control group(F(1,33)=0.740,p=0.396).The main effect of time was not significant in correct rate(F(1,33)=1.061,p=0.311),and no significant group×time interaction effect(F(1,33)=0.001,p=0.977).3.IGT net scores and Go / No go correlation analysis: In experimental group,there was no significant correlations between net scores of IGT and error rate of Go/No go task after taking pramipexole(r=0.376,p=0.167).Conclusion:1.Go / No go task demonstrate that taking pramipexole does not cause obvious behavioral impulsive in the short term.2.Iowa Gambling Task demonstrate that taking pramipexole does not cause obvious cognitive impulsive in the short term. |
