The Clinical Significance Of Serum Ferritin Levels In The Newly Diagnosed Multiple Myeloma

Background and Objective:Multiple myeloma(Multiple myeloma, MM) is a cancer which derives from plasma cells. Its clinical symptoms and cytogenetic performance vary largely. There are many prognostic factors in it. A single factor is not sufficient to determine its prognosis. It is necessary to combine different factors when staging and risking stratification with patients. Therefore, to explore new prognostic factors makes sense to the diagnosis and treatment of MM. Serum ferritin plays an important role in the storage of iron, inflammation and tumors. SF can be used as an adverse prognostic factor in the malignant hematopoietic diseases, and contribute to the monitoring of the tumor burden and efficacy. By observing the SF levels of newly diagnosed multiple myeloma patients, and analyzing the relationship between the SF levels and both the characteristics of MM patients and efficacy, the ultimate purpose is to demonstrate the significance of the SF in the diagnosing and efficacy monitoring of MM. Methods:Collected the clinical dates of 87 newly diagnosed multiple myeloma in our hospital, the time period is from January of 2009 to December of 2015, which including analyzing the relationship between the SF levels and clinical characteristics of newly diagnosed MM patients, and also the prognosis. SPSS 18.0 software is used. When describing the statistical properties of measurement data: use mean(`X±S) deviation if meeting the normal distribution, otherwise medians. When two samples were compared, using t-test if the two samples both submit to normal distribution, otherwise using nonparametric rank sum test. Correlation analysis uses Spearman test. P <0.01 is considered statistically significant in correlation analysis,while in others P <0.05 is considered statistically significant. Results:There are 55 males and 32 females in 87 patients. The mean age is 58.32 ± 10.73 years. Bone pain, dizziness and fatigue are the most common symptoms in newly diagnosed patients, 39 and 18.3 percent respectively. Most of the untreated patients have moderate anemia, accounting for 43.7%.There are 72.4% of patients in the Durie-Salmon(DS) ? period and 47.1% of patients in the International Staging System(ISS) ? period. IgG is the most common type, accounting for 46%.The SF levels are linearly correlated with the blood creatinine, blood lactate dehydrogenase(LDH), C Reactive protein(CRP), serum- microglobulin(?2-Mg), stages, efficacy using Spearman multiple correlation analysis. The higher group and the lower group of SF levels have no difference in the distribution of the age,gender, hemoglobin, platelet,lymphocyte absolute number,albumin and plasma cells of the bone marrow. While the distribution of serum calcium, serum LDH, serum creatinine, CRP, ?2-Mg, type, stages and curative effect make difference. Conclusions:1. The increasing of SF in MM maybe due to the tumor-associated inflammation.2. SF may reflect the tumor burden of MM,and also can be used for the efficacy monitoring and the prognostic evaluation of MM.