Efficacy Of Fuzhenghuayu Capsules Combined With Nucleos(t)ide Analogue In Patients With Hepatitis B Cirrhosis Compensatory Phase

Objective:To investigate the one year efficacy of Fuzhenghuayu Capsules combined with nucleos(t)ide analogue(NA)in patients with hepatitis B cirrhosis compensatory phase.Methods: One hundred patients with HBV related liver cirrhosis who had received NAs for more than 2 years and achieved sustained virological response(SVR)but with abnormal Serum markers of liver fibrosis were randomly divided into two groups:NAs plus Fuzhenghuayu capsule(FZHY) and NAs only for 48 weeks; Liver function, HBV-DNA level, Serum fibrosis markers(hyaluronic acid(HA), amino terminal propeptide of type ? procollagen(P?P), IV collagen(? C) and laminin(LN)) and B ultrasonic wave were observed before(baseline)and after treatment.43 patients were accepted liver biopsy.Results: 1. There was no significant difference of baseline index between two groups(P>0.05).After 24 weeks' treatment, all the index was not significantly different between two groups(P>0.05). 2. After 48 weeks' treatment, liver function was not significantly different between two groups(P>0.05). HBV-DNA level of all the patients was lower than 5×102copy/ml and was not significantly different between two groups(P>0.05). 3. After 48 weeks' treatment, the levels of all of the serum fibrosis markers(HA?PC??? C and LN),portal vein inner diameter and spleen thickness were lower in the experimental group(P<0.05) and lower than the baseline levels(P<0.05). 4. 22 cases in the experimental group accepted liver biopsy before and after 48 weeks' treatment, and 63.6% showed improvement in liver fibrosis stages. 21 cases in the control group accepted liver biopsy before and after 48 weeks' treatment, and only 14.3% showed improvement in liver fibrosis stages. There was significantly difference between two groups(P<0.05).Conclusions: For patients with HBV related liver cirrhosis who achieve SVR by antiviral treatment with NAs, but unsatisfactory improvement in liver fibrosis indices,combining Fuzhenghuayu capsule with continued NAs therapy may represent effective treatment.