Clinical Research Of Xingzhiruanmaikeli Treatment Of Cerebral Infarction Patients With Carotid Atherosclerosis

Objectives:1. observing XZRMKL treatment of cerebral infarction patients with carotid artery plaque morphology, properties, inside- such as film thickness in the change, evaluate its clinical efficacy;2. observing XZRMKL mechanism in patients with cerebral infarction;3. observing XZRMKL the safety of the treatment of cerebral infarction patients with carotid atherosclerosis.Methods:62 cases of cerebral infarction patients with carotid atherosclerosis were randomly divided into treatment group and control group, control group given worship of aspirin(bayer health care company, J20080078) approved by the state 100 mg, once a day,oral. Simvastatin(hangzhou MSD pharmaceutical co., LTD., approved by H19990366)10 mg, oral every night time; Treatment group(group XZRMKL) in the control group on the basis of given(: DANNANXING, ZHIBANXIA, JIANGCAN, SANQI,DANSHEN, GUIJIANYU, SHUIZHI; drug sources from bozhou city JIREN company provide Chinese medicine granules). A blunt, twice a day, treatment for 6 months.Observe the two groups before and after treatment in patients with carotid plaques Crouse integral, IMT and plaque stability, plaque area, vascular stenosis rate, blood lipids, hemorrheology, C-reactive protein, Hcy, blood coagulation four indices such as,BI, TCM syndrome integral change.1, by comparing before and after treatment in patients with carotid artery plaque Crouse integral, IMT and plaque stability, the section of the large area, analysis XZRMKL intervention clinical utility of carotid atherosclerosis.2, through comparison before and after treatment in patients with cholesterol, blood rheology, C- reactive protein, Hcy, coagulation index changes, such as analysis of the mechanism of action of XZRMKL.3, observation XZRMKL pap index on the patients and the effect of TCM syndrome integral.Results:1. the related parameters of ultrasonic changes:1.1 compared with before treatment, the treatment group and control group after treatment aspect is the most widespread Crouse integral, plaques(Smax)(was) scores were lower, plaque stability improvement; Compare two groups after treatment, the treatment group improved more significantly(P < 0.05).1.2 compared with before treatment, the treatment group and control group after treatment showed no improvement IMT, but did not continue to deteriorate; Two groups after treatment(P > 0.05), no statistical significance.2 blood index changes2.1 blood lipid index changes, the treatment group can significantly decrease TC and TG, increase HDL- C, lower TC, LDL- C and increase HDL- C curative effect is superior to the control group(P < 0.05).2.2 The change of CRP and Hcy, compared with before treatment, two groups of serum C-reactive protein levels and Hcy levels were decreased(P < 0.05 or P < 0.01);Compared with the control group after treatment, the treatment group CRP decreased more significantly(P < 0.05)2.3, The change of blood rheology two groups compared with before treatment, The control group compared with before treatment, plasma viscosity, whole blood low shear viscosity, whole blood high shear viscosity was also decreased to different degrees(P < 0.05), but the treatment group decreased more significantly(P < 0.01);Comparing the two groups after treatment, the treatment group whole blood low shear viscosity, plasma viscosity, whole blood high shear viscosity reduced more significantly(P < 0.05 or P < 0.05)2.4 blood coagulation function and the effect of the treatment group compared with before treatment, PT, APTT, TT time prolonged(P < 0.01, P < 0.05); The control group compared with before treatment, PT, APTT prolonged(P < 0.05), TT extension is not obvious(P > 0.05); Comparing the two groups after treatment in treatment group,PT, APTT, TT extend more obvious(P < 0.05); Both groups decrease is more FIB(P <0.01, P < 0.05), treatment group was more significant(P < 0.01).3. the BI and TCM syndrome integral change,The treatment group and control group BI was improved the; More obvious treatment group compared with control group,with statistical significance(P < 0.05 or P < 0.01). Change of syndromes, the treatment group than the control group in terms of TCM symptoms, Chinese medicine symptom integral were improved significantly(P < 0.05 or P < 0.01).4 safety indicators Compared two groups of patients before and after treatment, all different levels increased transaminase, was statistically significant(P < 0.05), but the results are within the normal range, the comparison between the two groups had no statistical significance(P > 0.05); CK, renal function, blood routine indexes between the two groups before and after treatment comparison and groups has no statistical significance(P > 0.05).Conclusion:(1) XZRMKL can reduce cerebral infarction patients with carotid atherosclerosis Crouse integral, reduce plaque largest area, reduce the number of unstable plaque, but for the role of IMT is uncertain.(2) XZRMKL can reduce the patients with carotid artery atherosclerosis of LDL- C,HCY, CRP levels; Elevated TG, HDL levels.(3) XZRMKL can improve blood coagulation function and hemorrheology in patients with related indicators.(4) XZRMKL better improve TCM syndrome integral and BI value?(5)XZRMKL for the treatment of cerebral infarction patients with CAS, the incidence of adverse reactions to no statistical difference compared with controls, XZRMKL used for clinical purposes is safe.