Angiogenesis In Skin Of Psoriasi And ?-amyloid Protein

Psoriasis is a common yet complex inflammatory dermatosis that may be seen in infants,children,and adolescents.The clinical presentation and course may be quite variable.Psoriasis can present in multiple forms:chronic plaques,intertriginous,pustular,erythrodermic,and guttate subtypes.Systemic associations include arthritis with the skin and joint disease having psychological sequelae.According to its presents,it can be divided into four kinds:psoriasis vulgaris,psoriatic arthritis,psoriasis pustulose,psoriasis erythrodermicum.Psoriasis is an immunological disease dominated by polygenes.Its pathogenesis is complicated,unclear,and associated with vascular endothelial growth factor(VEGF)as well as many immune cells such as T cells and dendritic cells.The most specific histopathological changes that distinguish psoriasis from other inflammatory skin diseases are excessive hypeiplasia of keratinocyte,aggregation of inflammatory cells and dermopapillary vascularization and expansion.Alzheimer's disease(AD)is the most common form of dementia among the aging population and is characterized pathologically by the progressive intracerebral accumulation of A? peptides and neurofibrillary tangles.Beta-amyloid peptides(A?)are the major constituents of senile plaques and cerebrovascular deposits in the brains of Alzheimer's disease patients.A(3 can be produced by some kinds of cells.Up to now,there is no research indicating that A? are present in diseases except Alzheimer's disease(AD).Our experiment is performed to explor the proliferation effects of(?-amyloid protein in psoriasis by Immunohistochemistry.ObjectiveTo explor the proliferation effects of(3-amyloid protein to angio-proliferation in psoriasis by Immunohistochemistry.MethodsThe skin tissues were from patients with psoriasis.We perform immunohistochemistry on the tissues to deserve the presence of the ?-amyloid protein.And then,we contrast the presence of(?-amyloid protein in skin tissues of psoriasis with that of normal people.ResultsIn the skin tissues of 42 patients with psoriasis,the presence of ?-amyloid protein were positive in the tissues of 19 patients.However,in the skin tissues of all normal people,the presence of ?-amyloid protein were negative.Meanwhile,?-amyloid protein was mostly localized on the microvascular.ConclusionsIn the skin tissues of patients with psoriasis,the presence of ?-amyloid protein were positive ? but that were negative in the skin tissues of normal people.The result shows that to some extent,?-amyloid protein is relative.This maybe relates to vascular proliferation.