Clinic Research On Executive Function And Event-related Potential In Patients With Subcortical Ischemic Vascular Cognitive Impairment No Dementia

Objective : Aim of the paper is to analyze features of executive dysfunction and characteristics of the main wave N2,P3 in Go/Nogo paradigm event-related potential in patients with subcortical ischemic vascular cognitive impairments with no dementia,in order to improve the level of diagnosis in subcortical ischemic vascular cognitive impairments with no dementia. Methods: Select 30 patients for case group,these patients were neurology outpatients and inpatients and were definitely diagnosed with subcortical ischemic vascular cognitive impairments no dementia(SIVCIND) in Southwest Medical University. Another 30 normal control(NC) matched with the gender,age and education. All patients completed the tests: 1, Evaluation of general cognitive function: Both two groups had to finish two tests:Mo CA, MMSE; 2, Neuropsychological executive function test :(1) Task switching:Trail Making Test(TMT),(2) Response inhibition:The Stroop Test(Stroop test),(3) Working Memory :2-back task; 3, ERPs: Analyzing the N2 and P3 components of event-related potentials during the response(Go) and inhibition of response(Nogo) to different stimuli;4,Compeled correlation analysis.Result: 1.SIVCIND group and NC group has no statistical significance in general data,such as age,gender, level of education(P >0.05). 2. Overall cognitive assessments :SIVCIND group got lower scores in MMSE,Mo CA compaired with NC group,and the difference statistically significant(P <0.01). Item of Mo Ca compairsion: SIVCIND group did worse in executive function, attention,memory and abstract(P <0.05), whereas no differences in Naming, linguistic function and orientation compared with the control group(P >0.05). 3.Neuropsychology executive function test :(1) Trail Making Test(TMT) : Compared with NC group,reaction time was prolonged in TMT-A,TMT-B(P <0.01),and TMT interference quantity was increased(P <0.01) in SIVCIND group and the difference is statistically significant;(2)Stroop test: Reaction time prolonged(P <0.01), omission rate and error rate increased significantly under conflict condition(P <0.01) in SIVCIND group compared with NC group.(3)2-back task :SIVCIND group did worse in 2-back task and the error rate increased significantly compared with NC group(P <0.01). 4.Go/Nogo ERPs:(1)Compaired wave components in different task in NC group : T-test indicated a significant difference in wave amplitude between Go and Nogo task, Nogo-N2>Go-N2(P <0.01),Nogo-P3>Go-P3(P <0.01). Compaired wave components in different task in SIVCIND group:There was no significant difference in wave amplitude between Go and Nogo task, Nogo-N2>Go-N2(P>0.05), Nogo-P3>Go-P3(P >0.05).(2)Compaired latency and amplitude of N2 and P3 between two groups in Go task: Go-P3 latency prolonged and Go-P3 amplitude declined in SIVCIND group compared with the control group(P <0.05); N2 wave latency and amplitude beween two group observed in Go task had no significant differences.Compaired latency and amplitude of N2 and P3 between two groups in Nogo task: Go-P3 latency prolonged and Go-P3 amplitude declined in SIVCIND group compared with the control group(P <0.01). Nogo-N2 latency prolonged and Nogo-N2 amplitude declined in SIVCIND group compared with the control group(P <0.01). 5. The correlation between Neuropsychological executive function tests and ERP : Latency and amplitude of Go-P3,Nogo-N2 and Nogo-P3 was correlated with Trail Making Test,Stroop test and 2-back task. Conclusions:1, SIVCIND patients did worse in general assessment in executive function,attention,memory and abstract. 2, executive function test: Task-switching,response inhibition and menmory refresh had impairment in SIVCIND patients.3, The disorder features of ERPs in SIVCIND patients: Nogo prepositional effect disapperaed,while Go-P3,Nogo-N2,Nogo-P3 latency extended and amplitude decreasesd. 4, Latency and amplitude of Go-P3,Nogo-N2 and Nogo-P3 was correlated with Trail Making Test,Stroop test and 2-back task. Therefore, Go-P3,Nogo-N2 and Nogo-P3 well reflected different aspects of executive function in subcortical ischemic vascular cognition impairment no dementia.