Study The Value Of 1.5T MR T2WI Combined With Functional Imaging In Diagnosis Prostate Disease

Objective: Study the value of 1.5T MR T2WI combine functional imaging in diagnosis of prostate disease. Methods: Collect 53 cases with benign prostatic hyperplasia(prostate hyperplasia group), 42 patients with prostate cancer(cancer of the prostate group) and 22 cases of normal prostate(control group), all cases have pathological results.All cases take examine on Philips 1.5T MR scanner with routine MRI sequencs and DWI sequencs.43 cases of benign hyperplasia of prostate and 32 cases of prostate cancer under MRS examination. Measure the value as follows:(1) DWI and ADC values: measure the ADC value of benign prostatic hyperplasia ? prostate cancer group and the control group.The ADC values of bening prostatic hyperplasia?prostate cancer and control group under two independent sample t-test.For prostate cancer group and bening prostatic hyperplasia group of ADC values,draw the ROC curve, get the best threshold ADC value and its diagnostic value,concluded the sensitivity, specificity, positive predictive value, negative predictive value and accuracy.(2) MRS: measured the metabolites of prostate, peaks of((Cho+Cre))/Cit value using independent sample t-test,ROC curve drawing, determine the best threshold ADC value and its diagnostic value, concluded the sensitivity, specificity, positive predictive value, negative predictive value and accuracy.(3) Compare analysis thethe value of sensitivity, specificity, positive predictive value, negative predictive value and accuracy of T2WI, DWI, MRS and T2WI combined DWI and MRS. Result:(1) The ADC value of benign prostate hyperplasia group, prostate cancer group and control group are:(1.250±0.263)×10-3mm2/s?(0.955±0.191)×10-3mm2/s and(1.558±0.173)×10-3mm2/s. The sensitivity, specificity, positive predictive value, negative predictive value and accuracy of threshold(ADC values = 1.095×10-3mm2/s) in differential diagnosis of prostate cancer group and benign hyperplasia of prostate group were 83.3%, 71.7%, 70.0%, 84.4%, 76.8%.(2) The(( Cho+Cre))/Cit rate of prostate cancer group and benign prostate hyperplasia are 0.899±0.201 and 1.594±0.487,they have Statistical differences(t=12.207,P < 0.01).The sensitivity, specificity,positive predictive value, negative predictive value and accuracy of threshold(ADC values = 1.095×10-3mm2/s) in differential diagnosis of prostate cancer and benign hyperplasia of prostate were 90.6%, 69.8%,69.0%, 90.1%, 78.7%.(3) For parallel test:the sensitivity, specificity of T2WI combined with DWI and MRS were 99.7%?42.5%.For serioal test were 59.3%?98.7%.Conclusion:(1) Benign prostate hyperplasia, prostate cancer group and the control group of ADC values have statistical differences,measurement of ADC values can help the diagnosis of prostatic diseases;(2) Benign prostatic hyperplasia and prostate cancer group of(Cho+Cre)/Cit value have differences statistically significant,MRS scans and measurement(Cho+Cre)/Cit value can help the differential diagnosis of benign prostatic hyperplasia and prostate cancer;(3) T2WI combine DWI and MRS have higher sensitivity, specificity than T2WI, DWI or MRS sequence,can separate applications, has a broad application value. It has a broad clinical application value.