The Changes And Significance Of TPS And VEGF Levels After TACE In Patients With Hepatocellular Carcinoma

Objective: To explore the changes and significance of tryptase(TPS)and vascular endothelial growth factor(VEGF) levels in patients with hepatocellular carcinoma(HCC) before and after transcatheter arterial chemoembolization(TACE).Materials and methods: The levels of TPS and VEGF were detected in 40 patients with HCC 1 day before TACE and 1 day, 7 days, 28 days after TACE by using Enzyme-linked immune-sorbent assay(ELISA).Results: The levels of TPS and VEGF in this group 1 day before TACE, and 1 day, 7 days and 28 days after TACE were(4.92±2.57) ng/ml and(298.98±80.10) pg/ml,(3.31±1.75) ng/ml and(439.1±102.67) pg/ml,(3.14±1.67) ng/ml and(389.23±60.21)pg/ml, and(4.59 ±2.50) ng/ml and(291.15±88.31) pg/ml, respectively. The difference of the TPS and VEGF levels before and after TACE treatment was significant, respectively(F=25.92, p=0.000 and F=31.12, p=0.000). The levels of TPS decreased markedly on day 1 and day 7 after TACE and recovered to the pre-TACE level on day 28 after TACE, however, the levels of VEGF rose markedly on day 1 and day 7 after TACE and recovered to the pre-TACE level on day 28 after TACE.The levels of TPS and VEGF in the CR+PR group 1 day before TACE and 28 days after TACE were(4.34±1.26) ng/ml,(343.02±74.57) pg/ml and(3.54±1.15) ng/ml,(227.32±91.01) pg/ml, respectively. The levels decreased markedly after TACE(p<0.05); Reversely, the levels of TPS and VEGF in the SD+PD group were(5.09±2.86) ng/ml,(269.88± 76.21) pg/ml and(5.48 ± 2.73) ng/ml,(307.82 ± 75.65) pg/ml, respectively, which increased markedly after TACE(p<0.05).There is no correlation between TPS and VEGF levels before TACE(p>0.05).Conclusion: The levels of TPS and VEGF in patients with HCC after TACE treatment undergo dynamic changes. TPS and VEGF will be used as biomarkers for evaluation TACE response in HCC patients.