| At present,nano-material is one of the hot research topic of nanometer materials science,nanometer materials in the field of electrochemistry and electrochemical analysis because of its special physical properties and chemical properties are widely used.It is able to expand and enhance the current response of the electrode potential window signal,improving the sensitivity of the material,increase the stability of the electrode.Considering the importance of the electrochemical method of modified electrode in drug analysis application and versatility of nanometer materials modified electrodes,this paper mainly used gold,grapheme oxide,copper hydroxide nanowires as modified materials,in this paper anti-cancer drugs was studied and the electrochemical behavior of anti-inflammatory drugs,established a series of rapid,sensitive and quantitative method.The main contents are as follows:1.A modified gold electrode is fabricated by electrodeposition and drop-coating method,which denoted as L-Cysteine/Aucolloid/DNA/Chitosan?L-cys/Aucolloid/DNA/CS/Au/CME?.The modified electrode has good stability and reproducibility.The key factors affecting the experimental results are analyzed,the optimal experimental conditions were determined.Different electrochemical methods such as cyclic voltammetry,differential pulse voltammetry were used to investigate the electrochemical behaviors of IB on L-cys/Aucolloid/DNA/CS/Au/CME along with the electrochemical parameters calculated.Under the best experimental condition,the concentration of IB showed good linear relationships with the reduction peak current of IB in the range of 1×10-7–1.0×10-4 mol/L with the detection limit of 2.3×10-8 mol/L?S/N=3?.Whereby established a new sensitive electroanalytical method for determination of IB,the modified electrode was successfully applied for the determination of IB in some actual samples with satisfactory results.2.Graphene oxide was prepared by improved Hummer method and characterized,In the bare gold electrode?AuE?surface potential polymerized L-serine,then chitosan,gold nanoparticles and graphene oxide were modified on the electrode surface prepared mixture corresponding electrode?L-Serine/GNO/Nano-Au/Au/CME?.Investigated the electrochemical behavior of cytosine on the L-Serine/GNO/Nano-Au/Au/CME,under the optimum experimental conditions,solved the related electrochemical parameters.Under the optimum experiment conditions,cytosine reductive peak current and its concentration in 1.0x10-71.0x10-3 mol/L range show good linear relationship,detection limit was 3.2x10-8 mol/L?S/N=3?.Results show that the presence of graphene oxide and nano gold electrode surface effectively improves the electrochemical response of cytosine,established a sensitive new method for determination of cytosine,the results show that this method is not only the operation is simple,reproducible,and wide linear range,high sensitivity,and can be used for the determination of cytosine in drug analysis.3.A Cu?OH?2 nanowires modified gold electrode?Cu?OH?2-NW-AuE?was prepared by using Cu?OH?2 nanowires as the modifier,which was further decorated with N,N-dimethylacetamide as the binder and through drop-coating method to get a modified electrode denoted as Cu?OH?2-NW-AuE.Electrochemical performance of Cu?OH?2-NW-AuE was greatly enhanced due to the presence of Cu?OH?2 nanowires.The characteristics of Cu?OH?2-NW-AuE were performed by using the cyclic voltammetric and SEM.Different electrochemical methods such as cyclic voltammetry,differential pulse voltammetry were used to investigate the electrochemical behaviors of VDS on Cu?OH?2-NW-AuE along with the electrochemical parameters calculated.The effects of scan rate and concentration on redoxtion peak current of VDS were investigated.Under the optimal conditions the redoxtion peak current of VDS was proportional to its concentration in the range from 1×10-8–1.0×10-4 mol/L with the detection limit of 4.5×10-9 mol/L?S/N=3?.Whereby established a new sensitive electroanalytical methodology method for determination of VDS. |
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