Pharmaceutical Research Of Penyankang Suppository

Penyan Kang Suppository is ording to the clinical practice of the affiliated hospital of the Chengdu University of traditional Chinese medicine.It is composed of Sargentodoxa cuneata, Radix Salivae, Patrinia scaniosaefolia, dandelion, corydalis tuber, trigone6 pieces medicine composition, with detoxification dehumidification, qi Huoxuezhitong, eliminate disease Sanjie. Clinic for chronic pelvic inflammatory disease, endometriosis due to the lower abdomen and lumbosacral pain, pelvic mass, dysmenorrhea, infertility. The topic have been studied about the preparation process, quality standards and stability tests.In the extraction process, With orthogonal test was adopted, the content of chlorogenic acid, Salvianolic acid B and dry extract rate was used as the indexes to optimize water extraction technology of Penyankang suppository and the content of tetrahydropalmatine, and dry extract rate regard as the indexes to optimize ethanol extraction technology.Extraction times had significant influence on water extraction effect, but the amount of water and extraction time had not significant influence.Optimum water extraction technology of Penyankang suppository was as follows:extracted two times with eight times the amount of water, one hour each time; In the ethanol extraction process, the ethanol concentration had some influence, extraction time and ethanol volume had not significant influence.Optimum ethanol extraction technology of Penyankang suppository was as follows:extracted two times with six times the amount of 60% ethanol, one hour and a half each time.In the molding process was as follows:adeps solidus was used to be the matrix, with the content ofl.0% Polysorbate 80 and 0.1% Sorbic acid, the molding process of Penyankang suppository was in water bath at 50?.After mixing, filling the mold. Take it to the icebox, cooling 10-20min, then, it is completed.In the quality standard and accelerated stability studies, we established TLC to Established Corydalis, Salvia four flavor Pieces TLC methods and determination of the method of Salvia natriuretic peptide. We carried out 6 months accelerated stab ility according to the standard. The results show that the preparation process is sci entific, reasonable, quality control, stability.