The Clinical Studies Of Dexmedetomidine Pretreatment On Hyperagesia Indueced After Remifentanil Annesthesia

Objective:To investigate the effects of dexmedetomidine given after remifentanil anesthesia of hyperalgesia.Methods:AS A ??? grade elective hysterectomy 40 patients were randomly divided into experimental group and control group(n=20),the experimental group before the end of surgery 40min given dexmedetomidine 0.8 ug·kg-1,the control group received the same amount of physiological saline at the same point in time.Observation:(1) Anesthesia time, surgery time, recovery time, extubation time; (2)in patients after extubation 0 min,15min, 30min,lh,2h,,12h and 24h VAS scores at each time point and Ramsay sedation score;(3)apply after extubation loading does with 2 h PICA times and effectively pushing the number of times 24h;(4)24h postoperative incidence of adverse reactions.Results:The two groups of patients with anesthesia time,surgery time,recovery time and extubation time was no significant difference(P>0.05);experimental group after extubation 0min,15min,30min,1h and 2h of VAS score was significantly lower than the control group (P<0.05),12 h and 24 h VAS scores than the control group had no significant difference(P>0.05);groups of patients at each time point after extubation Ramsay scores were not significantly different (P>0.05).Compared with the control group,the experimental goup PICA after extubation with 2 h additional loading does and with 24 h PCIA valid press number was significantly reduced (P<0.05),the incidence of adverse reactions was signicantly lower than the control group(P<0.05).Conclusion:Pretreatment given dexmedetomidine can reduce the amount of postoperative pain medication use,reduce the incidence of postoperative adverse reactions and improve postoperative analgesia, can effectively prevent pain of remfentanil anesthesia allergy.