To Assess The Value Of Detecting Anca And Asca For The Diagnosis Of Adult Ulcerative Colitis And Crohn’s Disease

Objective:there may have good correlation between ASCA, ANCA and inflammatory bowel disease,to comfirm it by means of meta analysis.Method:Pubmed, Ebase,etc were searched for relevant trials published on which before 2014, The QUADAS-2 tool was used to assess the risk of bias, Meta-Disc1.4 statistical software was applied to calculate heterogeneity and pooled sensitivity, specificity, positive likelihood ratio, negative likelihood ratio and diagnostic odds ratio, draw the subjects worker curve and calculating the area under the curve.Result:After screening 93 studies,13 studies were identified, The pooled sensitivity, specificity, positive and negative likehood ratio, diagnostic odds ratio of ANCA were calculated for differentiating UC from CD and controls (0.51,0.92,6.06,0.53,12.56,0.79). and ASCAfor differentiating CD from UC and controls (0.56,0.92,5.13,0.51,10.33,0.8169).Conclusion:ANCA and ASCA are useful in confirming the diagnosis of IBD, the suspect cases can choose this method, we give treatment early if the conclusion is positive,which is negtive apply to Colonoscopy.But more Prospective、double-blind、large-size also required to evaluate its clinical value.